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NMI Knockout Cell Lines

Gene: NMI

Official Full Name: N-myc and STAT interactorprovided by HGNC

Gene Summary: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00398 NMI gRNA6 KO plasmid NMI $850
GP00399 NMI gRNA5 KO plasmid NMI $850
KO01007 NMI Knockout cell line (THP-1) Human NMI 1:2-1:4 Negative Online Inquiry
KO15703 NMI Knockout cell line (HeLa) Human NMI 1:3~1:6 Negative Online Inquiry
KO15704 NMI Knockout cell line (HCT 116) Human NMI 1:2~1:4 Negative Online Inquiry
KO15705 NMI Knockout cell line (HEK293) Human NMI 1:3~1:6 Negative Online Inquiry
KO15706 NMI Knockout cell line (A549) Human NMI 1:3~1:4 Negative Online Inquiry

Background

NMI Gene Knockout Cell Lines are genetically modified cell lines where the NMI (N-myc Interactor) gene has been selectively disrupted to study its biological functions and regulatory mechanisms. By utilizing CRISPR-Cas9 gene-editing techniques or other advanced knockout methodologies, these cell lines provide a robust platform for researchers to investigate the role of NMI in cellular signaling, proliferation, differentiation, and responses to external stimuli.

The key function of these knockout cell lines lies in their ability to reveal the underlying biological pathways influenced by NMI. As a known regulator involved in oncogenesis and immune responses, the disruption of this gene allows researchers to analyze phenotypic changes that can illuminate the complexities of cancer biology and immune function. This can provide crucial insights into therapeutic targets and potential interventions.

The scientific importance of NMI Gene Knockout Cell Lines is evident in both research and clinical settings, where they are used to identify novel drug targets, understand cell signaling cascades, and contribute to biomarker discovery. Their applications extend to cancer research, immunology, and the development of regenerative therapies, providing invaluable tools in both fundamental and applied bioscience.

What sets these cell lines apart from standard cell models is their precision and specificity. They deliver consistent results that can enhance the reproducibility of experimental outcomes, thus leading to more reliable conclusions, which is paramount in the competitive landscape of biomedical research. Furthermore, commercially available NMI knockouts are often optimized for ease of use, stability, and scalability, making them ideal for both small-scale experiments and larger, high-throughput screenings.

For researchers and clinicians alike, the value of NMI Gene Knockout Cell Lines lies in their ability not only to deepen understanding of complex biological systems but also to accelerate the discovery of new therapeutic modalities. With a firm commitment to advancing scientific knowledge, our company specializes in offering high-quality, customized biological products like these knockout cell lines, grounded in rigorously validated methodologies and expertise in gene editing technologies.

Please note that all services are for research use only. Not intended for any clinical use.

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