Gene: NKD2
Official Full Name: NKD inhibitor of WNT signaling pathway 2provided by HGNC
Gene Summary: This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The encoded protein participates in the delivery of transforming growth factor alpha-containing vesicles to the cell membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11723 | NKD2 Knockout cell line (HCT 116) | Human | NKD2 | 1:2~1:4 | Negative | Online Inquiry |
KO11724 | NKD2 Knockout cell line (HEK293) | Human | NKD2 | 1:3~1:6 | Negative | Online Inquiry |
KO11725 | NKD2 Knockout cell line (A549) | Human | NKD2 | 1:3~1:4 | Negative | Online Inquiry |
NKD2 Gene Knockout Cell Lines are genetically engineered cell models designed to specifically disrupt the NKD2 gene, which has been implicated in various signaling pathways related to cellular development, differentiation, and oncogenesis. By utilizing CRISPR-Cas9 technology to achieve precise gene deletion, these cell lines serve as vital tools for researchers investigating the functional roles of the NKD2 gene in cellular processes and disease mechanisms.
The primary function of NKD2 Gene Knockout Cell Lines involves their utility in elucidating the pathways regulated by NKD2, particularly in relation to Wnt signaling, which is crucial for cell proliferation and tumorigenesis. Researchers can observe the consequential biological effects when NKD2 is knocked out, providing insights into its potential role as a tumor suppressor or an oncogene in various cancer types. This gene knockout model allows for targeted studies examining phenotypic changes, gene expression profiles, and responsiveness to therapeutics, thereby fostering advancements in both basic and translational research.
From a scientific perspective, the importance of NKD2 Gene Knockout Cell Lines is underscored by their applications in drug discovery, cancer research, and gene function analysis. They facilitate high-throughput screening of small molecules and the evaluation of novel therapeutic targets specific to diseases where NKD2 is a contributor.
What sets these cell lines apart from alternatives is their specificity and reliability, achieved through rigorously characterized knockout methodologies. Unlike other gene knockdown strategies, such as siRNA or shRNA, which may lead to incomplete inhibition or off-target effects, NKD2 Gene Knockout Cell Lines provide a definitive and stable model, ensuring reproducibility in experimental results.
For researchers and clinicians seeking to deepen their understanding of gene function, cell signaling, and therapeutic modalities, NKD2 Gene Knockout Cell Lines represent a substantial resource. Their ability to clarify biological pathways and support innovative research into cancer therapies likewise enhances their value in academic and pharmaceutical settings.
Our company specializes in the production of high-quality, well-characterized biological products, and we are committed to advancing scientific research through innovative solutions. The expertise our team brings in gene editing technologies ensures that you have access to the most reliable models for your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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