Home / NHERF4 Knockout Cell Lines

NHERF4 Knockout Cell Lines

Gene: NHERF4

Official Full Name: NHERF family PDZ scaffold protein 4provided by HGNC

Gene Summary: Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR; MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).[supplied by OMIM, Mar 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO15756 NHERF4 Knockout cell line (HeLa) Human NHERF4 1:3~1:6 Negative Online Inquiry
KO15757 NHERF4 Knockout cell line (HCT 116) Human NHERF4 1:2~1:4 Negative Online Inquiry
KO15758 NHERF4 Knockout cell line (HEK293) Human NHERF4 1:3~1:6 Negative Online Inquiry
KO15759 NHERF4 Knockout cell line (A549) Human NHERF4 1:3~1:4 Negative Online Inquiry

Background

NHERF4 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the function of the NHERF4 (Na+/H+ exchanger regulatory factor 4) gene in various biological processes. These knockout cell lines enable researchers to investigate the role of NHERF4 in cellular signaling, ion transport regulation, and its potential involvement in diseases. By selectively eliminating the NHERF4 gene, these cell lines serve as powerful tools for dissecting the molecular pathways influenced by this key regulatory protein.

The primary function of NHERF4 pertains to its role as a scaffolding protein, interacting with various membrane proteins and intracellular signaling molecules to modulate ion transporters and contribute to cell homeostasis. By utilizing NHERF4 knockout cell lines, researchers can elucidate how the absence of this protein affects cellular physiology, aiding in the understanding of complex cellular interactions and adaptations.

These cell lines hold significant scientific importance, especially in the context of studies focused on diseases such as cancer, cardiovascular disorders, and renal dysfunction, where dysregulation of ion transport and signaling pathways may play a pivotal role. In clinical settings, these models can facilitate the identification of potential therapeutic targets, fostering drug discovery and development initiatives aimed at correcting aberrant signaling associated with NHERF4.

What sets NHERF4 gene knockout cell lines apart from alternative models is their specific targeting of the NHERF4 gene, ensuring precise and reliable results that more general knockout models may not provide. This specificity enhances the scientific rigor of experiments and enhances reproducibility, crucial elements in research.

Researchers and clinicians will find immense value in these cell lines, not only for their applicability in elucidating fundamental biological processes but also for their potential to bridge the gap between basic research and clinical applications. With the promise of advancing therapeutic strategies, these models are indispensable for anyone aiming to deepen their understanding of complex biological systems.

Our company prides itself on its commitment to providing high-quality biological research tools, with extensive expertise in developing specialized cell lines that advance scientific discovery. By choosing NHERF4 Gene Knockout Cell Lines, you align with an organization dedicated to supporting cutting-edge research and clinical innovation.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.