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NFKBIB Knockout Cell Lines

Gene: NFKBIB

Official Full Name: NFKB inhibitor betaprovided by HGNC

Gene Summary: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36374 NFKBIB Knockout cell line (HeLa) Human NFKBIB 1:3~1:6 Negative Online Inquiry
KO36375 NFKBIB Knockout cell line (HCT 116) Human NFKBIB 1:2~1:4 Negative Online Inquiry
KO36376 NFKBIB Knockout cell line (HEK293) Human NFKBIB 1:3~1:6 Negative Online Inquiry
KO36377 NFKBIB Knockout cell line (A549) Human NFKBIB 1:3~1:4 Negative Online Inquiry

Background

NFKBIB Gene Knockout Cell Lines are advanced genetically modified cell lines designed to specifically disrupt the NFKBIB gene, which is critical in regulating NF-kB signaling pathways implicated in various cellular processes such as immune response, inflammation, and cell survival. By creating a knockout of this gene, these cell lines provide researchers the ability to study the effects of NFKBIB absence on cellular functions and disease mechanisms, offering insights into conditions ranging from cancer to autoimmune disorders.

The primary function of these cell lines involves the elucidation of the NF-kB signaling pathway. NF-kB proteins play pivotal roles in mediating responses to various stimuli, including stress, cytokines, and pathogens. By utilizing NFKBIB knockout cell lines, researchers can investigate the downstream effects of NF-kB activation or inhibition, particularly how the absence of NFKBIB influences cellular behavior, such as proliferation, apoptosis, and gene expression profiles. This can lead to a better understanding of how dysregulation in this pathway contributes to disease pathogenesis.

From a scientific standpoint, the applications of NFKBIB Gene Knockout Cell Lines span both research and clinical settings. They are invaluable for preclinical studies examining drug responses, the development of therapeutic strategies targeting NF-kB, and elucidation of the molecular underpinnings of various diseases. Moreover, these cell lines can serve as control models to validate outcomes observed in experimental designs involving NF-kB signaling.

What sets our NFKBIB Gene Knockout Cell Lines apart from alternatives is their robust genetic validation and high reproducibility, ensuring that results are both reliable and relevant. Our customization options allow for tailored experimental designs to fit researchers’ specific needs. Furthermore, these cell lines come with detailed characterization and user-friendly protocols, which lower the barrier to entry for scientists less familiar with knockout methodologies.

Investing in NFKBIB Gene Knockout Cell Lines opens up possibilities for groundbreaking research and therapeutic advancements, making them a vital asset for laboratories focused on cellular and molecular biology. Our company is dedicated to providing high-quality biological products backed by expertise in genetic engineering, ensuring that researchers receive not only superior products but also comprehensive support throughout their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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