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NFIB Knockout Cell Lines

Gene: NFIB

Official Full Name: nuclear factor I Bprovided by HGNC

Gene Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development and regulation of DNA-templated transcription. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36386 NFIB Knockout cell line (HeLa) Human NFIB 1:3~1:6 Negative Online Inquiry
KO36387 NFIB Knockout cell line (HCT 116) Human NFIB 1:2~1:4 Negative Online Inquiry
KO36388 NFIB Knockout cell line (HEK293) Human NFIB 1:3~1:6 Negative Online Inquiry
KO36389 NFIB Knockout cell line (A549) Human NFIB 1:3~1:4 Negative Online Inquiry

Background

NFIB Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to knockout the Nuclear Factor I B (NFIB) gene, a critical transcription factor involved in various cellular processes such as cell proliferation, differentiation, and apoptosis. These cell lines provide researchers with invaluable tools to study the functional roles of NFIB in biological pathways and disease processes.

The NFIB gene plays a significant role in regulating gene expression and has been implicated in numerous conditions, including cancer, neurodevelopmental disorders, and fibrosis. By utilizing these knockout cell lines, scientists can investigate the specific pathways disrupted by the absence of NFIB, providing insights into the underlying mechanisms of disease. The pragmatic utility of these cell lines extends into both basic research and clinical settings, facilitating the exploration of NFIB as a potential therapeutic target.

One of the key advantages of using NFIB Gene Knockout Cell Lines is their specificity and consistency in the knockout process, achieved through precise CRISPR/Cas9 technology. This leads to a high degree of reliability in experimental outcomes compared to other gene editing strategies that may yield off-target effects. Furthermore, these cell lines can be easily incorporated into various experimental systems, including in vitro assays and in vivo models, enhancing their versatility for diverse applications in research.

The growing body of evidence suggesting NFIB’s involvement in pivotal biological processes underscores the product's importance to researchers and clinicians alike. Using these knockout cell lines can help elucidate disease pathways, ultimately paving the way for novel therapies and diagnostic tools. With these powerful models, researchers can save valuable time and resources while advancing their understanding of NFIB's roles in health and disease.

Our company prides itself on its commitment to providing high-quality genetic tools and resources, backed by a team of experts in molecular biology. We offer a diverse array of biological products to support innovative research, making us a trusted partner in the scientific community as you explore the complexities of gene function and regulation.

Please note that all services are for research use only. Not intended for any clinical use.

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