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NEO1 Knockout Cell Lines

Gene: NEO1

Official Full Name: neogenin 1provided by HGNC

Gene Summary: This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11518 NEO1 Knockout cell line (HeLa) Human NEO1 1:3~1:6 Negative Online Inquiry
KO11519 NEO1 Knockout cell line (HCT 116) Human NEO1 1:2~1:4 Negative Online Inquiry
KO11520 NEO1 Knockout cell line (HEK293) Human NEO1 1:3~1:6 Negative Online Inquiry
KO11521 NEO1 Knockout cell line (A549) Human NEO1 1:3~1:4 Negative Online Inquiry

Background

NEO1 Gene Knockout Cell Lines are engineered cellular models that have had the NEO1 gene selectively disrupted to facilitate the study of its biological functions and implications in various disease pathways. These cell lines serve as invaluable tools for researchers investigating the role of NEO1 in cellular processes such as migration, differentiation, and neurodevelopment, as well as its potential implications in disorders like cancer and neurological diseases.

The key mechanism underlying these cell lines involves the use of CRISPR-Cas9 technology, which allows for precise editing of the NEO1 locus. By introducing double-strand breaks in the DNA at specific locations, researchers can achieve targeted deletion of the gene, resulting in a knockout phenotype. This alteration is crucial for elucidating the signaling pathways and molecular mechanisms regulated by NEO1, helping researchers to understand how its dysfunction may contribute to pathological conditions.

The scientific importance of NEO1 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical settings. They enable the exploration of gene function in a controlled environment and serve as a vital platform for drug discovery, toxicity testing, and molecular interaction studies. Researchers can utilize these models to validate therapeutic targets, assess drug responsiveness, and investigate gene-environment interactions.

One of the key advantages of our NEO1 Gene Knockout Cell Lines is their high specificity and reliability compared to traditional knockout models, which may exhibit variable expression levels or unintended off-target effects. Furthermore, our cell lines come with detailed characterization data, which enhances the reproducibility of experiments—an essential aspect of scientific research.

For researchers and clinicians engaged in gene function studies or therapeutic development, the availability of NEO1 Gene Knockout Cell Lines represents a unique opportunity to advance their understanding of complex biological systems. The high-quality nature of these cell lines ensures robust results that can significantly impact future research and clinical applications.

Our company specializes in the development and provision of cutting-edge biological tools that empower researchers in their quest for scientific discovery. With a commitment to quality and innovation, we strive to deliver products that facilitate groundbreaking research and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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