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NEDD9 Knockout Cell Lines

Gene: NEDD9

Official Full Name: neural precursor cell expressed, developmentally down-regulated 9provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02322 NEDD9 Knockout cell line (HeLa) Human NEDD9 1:3~1:6 Negative Online Inquiry
KO02323 NEDD9 Knockout cell line (HEK293) Human NEDD9 1:3~1:6 Negative Online Inquiry
KO02324 NEDD9 Knockout cell line (A549) Human NEDD9 1:3~1:4 Negative Online Inquiry

Background

NEDD9 Gene Knockout Cell Lines are specialized cellular models in which the NEDD9 gene, a member of the CAS family of proteins involved in cell signaling and adhesion, has been systematically inactivated. These cell lines are engineered using advanced CRISPR-Cas9 gene editing technology, ensuring precise deletion of the NEDD9 gene. By eliminating NEDD9, researchers can investigate the gene's role in critical cellular processes such as migration, proliferation, and tumorigenesis, providing essential insights into cancer biology and other pathophysiological conditions.

The key function of the NEDD9 gene is its involvement in the regulation of protein interactions that govern cytoskeletal organization and cell attachment to extracellular matrices. This gene is implicated in various signaling pathways, including those triggered by integrins and growth factor receptors. Consequently, the knockout of NEDD9 can dramatically alter cellular behavior, serving as a powerful tool for elucidating mechanisms underlying cancer metastasis and invasion.

The scientific importance of NEDD9 Gene Knockout Cell Lines extends to both basic and applied research. These cell lines can be utilized to model carcinogenesis, study responses to therapeutic agents, and decipher molecular pathways that could contribute to cancer treatment strategies. In clinical settings, insights gained from such models could inform the development of targeted therapies that interrupt aberrant signaling pathways linked to invasive cancer phenotypes.

Compared to traditional knockdown methods such as RNA interference, NEDD9 Gene Knockout Cell Lines offer a permanent and unequivocal genetic alteration, providing superior reliability and reproducibility in research outcomes. Their utility spans across diverse fields, making them a valuable addition to any laboratory focused on oncology or cell biology.

For researchers and clinicians alike, the opportunity to utilize these tailored cell lines presents a strategic advantage in the pursuit of groundbreaking discoveries. By understanding the molecular underpinnings of NEDD9's role, users can pioneer novel therapeutic strategies that could significantly impact patient care.

Our company, with a strong commitment to advancing research tools, specializes in providing high-quality biological products like NEDD9 Gene Knockout Cell Lines. Our expertise ensures that our customers can rely on us for innovative solutions that drive their research goals forward with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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