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NEBL Knockout Cell Lines

Gene: NEBL

Official Full Name: nebuletteprovided by HGNC

Gene Summary: This gene encodes a nebulin like protein that is abundantly expressed in cardiac muscle. The encoded protein binds actin and interacts with thin filaments and Z-line associated proteins in striated muscle. This protein may be involved in cardiac myofibril assembly. A shorter isoform of this protein termed LIM nebulette is expressed in non-muscle cells and may function as a component of focal adhesion complexes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31747 NEBL Knockout cell line (HeLa) Human NEBL 1:3~1:6 Negative Online Inquiry
KO31748 NEBL Knockout cell line (HCT 116) Human NEBL 1:2~1:4 Negative Online Inquiry
KO31749 NEBL Knockout cell line (HEK293) Human NEBL 1:3~1:6 Negative Online Inquiry
KO31750 NEBL Knockout cell line (A549) Human NEBL 1:3~1:4 Negative Online Inquiry

Background

NEBL Gene Knockout Cell Lines are specialized, genetically modified mammalian cells designed to facilitate precise gene editing by completely disrupting the NEBL (nebulin) gene. This innovative product allows researchers to explore the role of the NEBL gene in cellular processes such as muscle development, tissue integrity, and potential pathology in various diseases. The knockout mechanism is achieved through CRISPR/Cas9 technology, enabling efficient and reliable disruption of target sequences within the NEBL gene, which plays a pivotal role in the structure and function of striated muscles.

The key functions of NEBL Gene Knockout Cell Lines are based on the principles of gene editing, thereby allowing for in-depth investigations into gene function and the development of therapeutic strategies. The knockout model provides a powerful avenue for studying the downstream effects of NEBL ablation on cellular signaling pathways, muscle regeneration, and disease models, facilitating advancements in our understanding of muscular dystrophies and cardiomyopathies.

In research and clinical settings, the potential applications of NEBL knockout cell lines are vast. They can serve as invaluable tools for drug discovery, biomarker identification, and therapeutic assessments. Given the ongoing exploration of musculoskeletal disorders, such models are critical for elucidating the molecular underpinnings of muscle-related diseases, which may lead to novel therapeutic avenues.

The advantages of NEBL Gene Knockout Cell Lines over traditional knockout models include their enhanced efficiency in gene disruption, reproducibility of results, and ease of use within standard laboratory protocols. This product stands out in the marketplace due to its specificity, allowing for targeted research that minimizes off-target effects often associated with alternative gene-editing methods.

The value of NEBL Gene Knockout Cell Lines to researchers and clinicians lies in their ability to generate essential insights into the role of the NEBL gene, facilitating groundbreaking discoveries in muscle biology and disease treatment strategies. Coupled with our company’s commitment to delivering high-quality, reproducible biological tools backed by expert support, NEBL Gene Knockout Cell Lines represent a significant advancement in genetic research and application.

Please note that all services are for research use only. Not intended for any clinical use.

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