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NDUFV1 Knockout Cell Lines

Gene: NDUFV1

Official Full Name: NADH:ubiquinone oxidoreductase core subunit V1provided by HGNC

Gene Summary: The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02817 NDUFV1 Knockout cell line (HeLa) Human NDUFV1 1:3~1:6 Negative Online Inquiry
KO02818 NDUFV1 Knockout cell line (HCT 116) Human NDUFV1 1:2~1:4 Negative Online Inquiry
KO02819 NDUFV1 Knockout cell line (HEK293) Human NDUFV1 1:3~1:6 Negative Online Inquiry
KO02820 NDUFV1 Knockout cell line (A549) Human NDUFV1 1:3~1:4 Negative Online Inquiry

Background

NDUFV1 Gene Knockout Cell Lines are genetically modified cellular models characterized by the targeted disruption of the NDUFV1 gene, which encodes a key subunit of the mitochondrial NADH:ubiquinone oxidoreductase (complex I) in the electron transport chain. This biotechnological product serves as a vital tool for researchers studying mitochondrial dysfunctions and related metabolic disorders. By knocking out the NDUFV1 gene, these cell lines provide a controlled environment to investigate alterations in cellular respiration, ATP production, and overall mitochondrial health, facilitating the elucidation of complex pathological mechanisms linked to diseases such as Parkinson's, Alzheimer's, and various forms of cancer.

These knockout cell lines operate on the principle of CRISPR/Cas9 genome editing technology, allowing precise and reproducible generation of mutations in the target gene. This innovative mechanism enables researchers to systematically explore the functional implications of NDUFV1 loss, driving forward our understanding of metabolic reprogramming in health and disease. The cellular models generated from this technology are not only vital for investigating the biochemical pathways affected by mitochondrial dysfunction but also serve as a platform for drug screening and therapeutic interventions.

The scientific importance of NDUFV1 Gene Knockout Cell Lines extends beyond basic research; they are applicable in clinical diagnostics and in the development of targeted therapies that aim to restore mitochondrial function. Compared to other cell lines or models, our NDUFV1 knockout lines are specifically designed for ease of use, with comprehensive protocols available for optimal experimental conditions, ensuring reliability in results.

For researchers and clinicians, the value of this product lies in its ability to facilitate groundbreaking research while saving time and resources. By utilizing these specialized cell lines, investigators can accelerate their studies on mitochondrial diseases, ultimately leading to novel therapeutic strategies that could enhance patient outcomes.

Our company prides itself on its expertise in genetic engineering and cellular biology, offering high-quality biological products that support the advancement of scientific knowledge and innovative healthcare solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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