Gene: NDUFC1
Official Full Name: NADH:ubiquinone oxidoreductase subunit C1provided by HGNC
Gene Summary: The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36424 | NDUFC1 Knockout cell line (HeLa) | Human | NDUFC1 | 1:3~1:6 | Negative | Online Inquiry |
KO36425 | NDUFC1 Knockout cell line (HCT 116) | Human | NDUFC1 | 1:2~1:4 | Negative | Online Inquiry |
KO36426 | NDUFC1 Knockout cell line (HEK293) | Human | NDUFC1 | 1:3~1:6 | Negative | Online Inquiry |
KO36427 | NDUFC1 Knockout cell line (A549) | Human | NDUFC1 | 1:3~1:4 | Negative | Online Inquiry |
NDUFC1 Gene Knockout Cell Lines are specifically engineered cellular models that lack the functional NDUFC1 gene, which encodes for a crucial component of the mitochondrial respiratory chain complex I. This gene plays a pivotal role in the electron transport chain, facilitating ATP production through oxidative phosphorylation. By creating a knockout of the NDUFC1 gene, these cell lines provide researchers with an invaluable tool to study the metabolic consequences of disrupting mitochondrial function, a phenomenon often linked to various degenerative diseases, including neurodegenerative disorders and metabolic syndromes.
The key function of NDUFC1 Gene Knockout Cell Lines lies in their ability to mimic the pathological states observed in human diseases. These cell lines work by demonstrating the effects of impaired mitochondrial bioenergetics, which allows for the investigation of compensatory mechanisms that may arise in response to mitochondrial dysfunction. Researchers can utilize these models to explore cellular pathways, metabolic alterations, and potential therapeutic interventions to mitigate the impact of mitochondrial dysfunction.
In both research and clinical settings, understanding the mechanisms of diseases associated with mitochondrial deficits is paramount. NDUFC1 Gene Knockout Cell Lines serve as essential experimental systems for drug discovery, particularly in the development of compounds aimed at restoring mitochondrial function or protecting against oxidative stress. They also provide valuable insights into the biological pathways involved in cancer metabolism, aging, and inherited mitochondrial disorders.
What sets our NDUFC1 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, achieved through precise gene editing techniques that ensure a complete knockout without off-target effects. This level of accuracy facilitates reproducible results that researchers can trust, making them a preferred choice in the scientific community.
Researchers and clinicians are increasingly recognizing the importance of these cell lines, as they not only contribute to foundational knowledge in mitochondrial biology but also hold potential for translational applications that could lead to novel treatment strategies. Our company's expertise in gene editing and cellular engineering has enabled us to provide top-tier biological products like the NDUFC1 Gene Knockout Cell Lines, designed to support innovative research and advance the frontiers of biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
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