Gene: NCOA6
Official Full Name: nuclear receptor coactivator 6provided by HGNC
Gene Summary: The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. This protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO29949 | NCOA6 Knockout cell line (HeLa) | Human | NCOA6 | 1:3~1:6 | Negative | Online Inquiry |
KO29950 | NCOA6 Knockout cell line (HCT 116) | Human | NCOA6 | 1:2~1:4 | Negative | Online Inquiry |
KO29951 | NCOA6 Knockout cell line (HEK293) | Human | NCOA6 | 1:3~1:6 | Negative | Online Inquiry |
KO29952 | NCOA6 Knockout cell line (A549) | Human | NCOA6 | 1:3~1:4 | Negative | Online Inquiry |
NCOA6 Gene Knockout Cell Lines are genetically engineered cell models specifically designed to facilitate the study of the NCOA6 gene's role in various cellular processes and disease mechanisms. These knockout cell lines possess a silenced NCOA6 gene, ensuring that researchers can accurately assess the gene's functions, interactions, and contributions to physiological and pathological conditions.
The main function of the NCOA6 Gene Knockout Cell Lines lies in their ability to investigate the implications of NCOA6 deficiency on cellular behavior, gene expression, and signal transduction pathways. By leveraging CRISPR-Cas9 gene editing technology, these cell lines exhibit a precise and efficient genomic modification, which allows for detailed exploration of NCOA6's role as a coactivator in transcriptional regulation. This is particularly important in the contexts of cancer biology, metabolic disorders, and developmental biology, where the aberration of coactivators can lead to significant functional changes.
The scientific importance of these models cannot be overstated; they enable researchers in both academic and clinical settings to dissect the intricacies of gene regulatory networks and their impact on disease progression. With an increasing number of studies illuminating the implications of NCOA6 in oncogenesis and hormone signaling, these knockout cell lines serve as a vital tool for validating therapeutic targets and developing novel treatment approaches.
What sets NCOA6 Gene Knockout Cell Lines apart from other genetic models is their specificity and robustness. Unlike traditional knockdown strategies that may result in partial gene inhibition, our knockout cell lines ensure complete loss-of-function, providing clearer insights into NCOA6's biological roles. Moreover, these cell lines are compatible with a wide variety of applications including drug screening, gene expression profiling, and mechanistic studies, thus offering extensive versatility to researchers.
Investing in NCOA6 Gene Knockout Cell Lines empowers researchers and clinicians with the essential tools to push the boundaries of knowledge in their fields. The derived insights can lead to groundbreaking discoveries that drive advancements in personalized medicine and targeted therapies. At [Your Company Name], we pride ourselves on our commitment to excellence in the production of high-quality biological products and offer extensive expertise to support your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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