Gene: NCOA5
Official Full Name: nuclear receptor coactivator 5provided by HGNC
Gene Summary: This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02893 | NCOA5 Knockout cell line (HeLa) | Human | NCOA5 | 1:3~1:6 | Negative | Online Inquiry |
KO02894 | NCOA5 Knockout cell line (HCT 116) | Human | NCOA5 | 1:2~1:4 | Negative | Online Inquiry |
KO02895 | NCOA5 Knockout cell line (HEK293) | Human | NCOA5 | 1:3~1:6 | Negative | Online Inquiry |
KO02896 | NCOA5 Knockout cell line (A549) | Human | NCOA5 | 1:3~1:4 | Negative | Online Inquiry |
NCOA5 Gene Knockout Cell Lines are genetically modified cellular models designed to facilitate advanced research into the functions and implications of the NCOA5 gene, known to play a critical role in various biological processes, particularly in cancer development and metabolic regulation. These cell lines have been engineered to have a complete deletion of the NCOA5 gene, allowing researchers to study the resulting phenotypic changes and uncover mechanistic insights into NCOA5-mediated signaling pathways.
The primary function of these NCOA5 knockout cell lines is to serve as a functional platform for investigating gene interactions, signaling cascades, and metabolic processes linked to NCOA5 in both normal and pathological conditions. By removing the NCOA5 gene, researchers can explore alterations in cellular behavior, differentiation, and response to external stimuli, making these cell lines invaluable for studies in oncology and metabolic diseases.
The scientific importance of NCOA5 Gene Knockout Cell Lines cannot be overstated; they provide a pioneering tool that enhances our understanding of gene function in human physiology and disease. In clinical and research settings, they are essential for drug discovery, biomarker identification, and the development of targeted therapies, enabling researchers to test hypotheses related to gene expression and its effects on disease progression.
Compared to alternative models such as wild-type cell lines or those with partial gene silencing, NCOA5 knockout cell lines provide a more definitive and robust approach to elucidating the specific roles of NCOA5 without the confounding influences of residual gene activity. Furthermore, these knockout models offer reproducibility and reliability, which are critical for advancing therapeutic strategies and gaining regulatory approval.
In a landscape where precision medicine is paramount, NCOA5 Gene Knockout Cell Lines empower researchers and clinicians to push the boundaries of medical science. They can accelerate the development of innovative solutions tailored to complex diseases linked to NCOA5, providing significant value to the scientific community.
Our company prides itself on its commitment to excellence in the field of genetic research, developing high-quality products that support groundbreaking discoveries. With extensive expertise in creating genetically engineered cell lines, we are a trusted partner for researchers who seek to explore the intricate mechanisms governing health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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