Home / NBR1 Knockout Cell Lines

NBR1 Knockout Cell Lines

Gene: NBR1

Official Full Name: NBR1 autophagy cargo receptorprovided by HGNC

Gene Summary: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04560 NBR1 Knockout cell line (HeLa) Human NBR1 1:3~1:6 Negative Online Inquiry
KO04561 NBR1 Knockout cell line (HCT 116) Human NBR1 1:2~1:4 Negative Online Inquiry
KO04562 NBR1 Knockout cell line (HEK293) Human NBR1 1:3~1:6 Negative Online Inquiry
KO04563 NBR1 Knockout cell line (A549) Human NBR1 1:3~1:4 Negative Online Inquiry

Background

NBR1 Gene Knockout Cell Lines are meticulously developed cellular models that have been genetically modified to disrupt the expression of the NBR1 (Neighbor of BRCA1 Gene 1) gene. This gene plays a critical role in cellular processes, including autophagy, protein degradation, and innate immune response. By employing CRISPR-Cas9 technology or other gene-editing methods, these cell lines enable researchers to study the biological consequences of NBR1 loss and its implications in various pathologies, including cancer and neurodegenerative diseases.

The primary function of NBR1 Gene Knockout Cell Lines is to facilitate the investigation of the NBR1 gene's role in cellular signaling pathways and disease mechanisms. By eliminating the gene, researchers can observe alterations in cellular behavior, such as changes in protein aggregates, autophagic flux, and inflammatory responses. This provides insight into how disturbances in NBR1 expression contribute to disease progression and offers a platform for testing novel therapeutic interventions.

The scientific importance of these cell lines extends across multiple research fields, including cancer biology, immunology, and neurobiology. In clinical settings, they can serve as a valuable tool for drug discovery and development, particularly in understanding how therapies might be tailored to target NBR1-related pathways effectively.

One of the unique advantages of our NBR1 Gene Knockout Cell Lines is their superior specificity and reliability compared to conventional knockdown approaches, such as siRNA, which may induce off-target effects. Furthermore, these knockout models promote reproducibility in experimental outcomes, thereby increasing confidence in research findings.

For researchers and clinicians alike, the availability of NBR1 Gene Knockout Cell Lines can accelerate the understanding of disease mechanisms and foster innovative therapeutic strategies. By choosing our product, users benefit from a rigorously tested and validated resource that aligns with the highest standards of scientific integrity.

Our company prides itself on its commitment to biological research, demonstrated through a robust portfolio of genetic models and cutting-edge technologies that empower scientists in their quest for knowledge and discovery. With NBR1 Gene Knockout Cell Lines, we provide essential tools that not only enhance research quality but also pave the way for future breakthroughs in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.