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NBL1 Knockout Cell Lines

Gene: NBL1

Official Full Name: NBL1, DAN family BMP antagonistprovided by HGNC

Gene Summary: This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11522 NBL1 Knockout cell line (HeLa) Human NBL1 1:3~1:6 Negative Online Inquiry
KO11523 NBL1 Knockout cell line (HCT 116) Human NBL1 1:2~1:4 Negative Online Inquiry
KO11524 NBL1 Knockout cell line (HEK293) Human NBL1 1:3~1:6 Negative Online Inquiry
KO11525 NBL1 Knockout cell line (A549) Human NBL1 1:3~1:4 Negative Online Inquiry

Background

NBL1 Gene Knockout Cell Lines are specially engineered cell lines designed to have a complete disruption of the NBL1 gene, facilitating in-depth exploration of its biological function and contributions to various physiological and pathological processes. These cell lines utilize CRISPR/Cas9 technology, a powerful genome-editing tool that allows for precise modifications at specific locations in the DNA. By knocking out the NBL1 gene, researchers can investigate the downstream effects on cellular pathways, gene expression, and overall cellular behavior, making these models invaluable for understanding gene function and its implications in health and disease.

The NBL1 gene is known to play a significant role in developmental processes and has been implicated in certain cancers. In research settings, these knockout cell lines serve as a critical resource for elucidating mechanisms of tumorigenesis, identifying potential biomarkers for disease progression, and testing new therapeutic strategies. Their application extends into gene therapy research, functional genomics studies, and drug discovery, making them essential tools for both basic and translational science.

Compared to alternative models, such as wild-type cells or siRNA-based approaches, the NBL1 Gene Knockout Cell Lines offer unparalleled specificity and stability of the genetic modification, allowing researchers to achieve reproducible results. This specificity reduces off-target effects, thus enhancing the reliability of experimental data.

For researchers and clinicians focused on the intricacies of gene function and its clinical ramifications, these cell lines provide a robust platform for probing the complexities of cellular mechanisms. By choosing our NBL1 Gene Knockout Cell Lines, you gain access to a product that is not only scientifically viable but also backed by our team’s extensive expertise in molecular biology and genetic engineering. With a commitment to quality and innovation, we strive to support the scientific community with tools that drive discovery and advance research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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