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NBEAL2 Knockout Cell Lines

Gene: NBEAL2

Official Full Name: neurobeachin like 2provided by HGNC

Gene Summary: The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29695 NBEAL2 Knockout cell line (HeLa) Human NBEAL2 1:3~1:6 Negative Online Inquiry
KO29696 NBEAL2 Knockout cell line (HCT 116) Human NBEAL2 1:2~1:4 Negative Online Inquiry
KO29697 NBEAL2 Knockout cell line (HEK293) Human NBEAL2 1:3~1:6 Negative Online Inquiry
KO29698 NBEAL2 Knockout cell line (A549) Human NBEAL2 1:3~1:4 Negative Online Inquiry

Background

NBEAL2 Gene Knockout Cell Lines represent a cutting-edge advancement in genetic research, specifically designed to facilitate the study of NBEAL2 gene function and its roles in cellular processes. These specialized cell lines have been genetically engineered to produce a complete knockout of the NBEAL2 gene, allowing researchers to investigate the effects of its absence in various biological contexts, including disease modeling and therapeutic development.

The primary function of NBEAL2 Gene Knockout Cell Lines is to enable comprehensive analyses of the cellular mechanisms modulated by the NBEAL2 protein, which is implicated in functions such as platelet biogenesis and regulation of hemostasis. By utilizing CRISPR/Cas9 technology, these cell lines permit precise and efficient gene editing, resulting in a complete loss-of-function phenotype that researchers can leverage to explore downstream signaling pathways and identify potential compensation mechanisms.

The scientific importance of these cell lines is underscored by their potential applications in research and clinical settings. NBEAL2 is associated with various hematological disorders, including familial macrothrombocytopenia. Through the use of these knockout cell lines, scientists can elucidate the molecular pathways affected by NBEAL2 deficiency, paving the way for novel therapeutic approaches and targeted interventions in related diseases.

Compared to traditional methods of gene disruption, NBEAL2 Gene Knockout Cell Lines offer several advantages. They provide a standardized model that enhances reproducibility and facilitates high-throughput screening of potential therapeutics. Moreover, these cell lines can help uncover functional insights that might be obscured in systems with residual gene expression, thus delivering a clearer picture of NBEAL2's role in pathophysiology.

For researchers and clinicians, the value of NBEAL2 Gene Knockout Cell Lines is clear: they not only streamline the research process but also foster innovative discoveries that could lead to significant improvements in patient care. By investing in these advanced cell lines, users are better positioned to explore vital biological questions and accelerate the development of new treatment modalities.

Our company brings a wealth of expertise in genetic engineering and a commitment to providing high-quality biological products. With a focus on innovation and scientific rigor, we are dedicated to supporting your research endeavors and advancing the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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