Gene: NARF
Official Full Name: nuclear prelamin A recognition factorprovided by HGNC
Gene Summary: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05813 | NARF Knockout cell line (HeLa) | Human | NARF | 1:3~1:6 | Negative | Online Inquiry |
KO05814 | NARF Knockout cell line (HCT 116) | Human | NARF | 1:2~1:4 | Negative | Online Inquiry |
KO05815 | NARF Knockout cell line (HEK293) | Human | NARF | 1:3~1:6 | Negative | Online Inquiry |
KO05816 | NARF Knockout cell line (A549) | Human | NARF | 1:3~1:4 | Negative | Online Inquiry |
NARF Gene Knockout Cell Lines are specialized tools designed for precise genetic manipulation in research applications. These cell lines have been engineered through the targeted deletion of the NARF gene, which is critically involved in several cellular processes including metabolic regulation, signaling pathways, and cellular stress response.
The primary function of NARF Gene Knockout Cell Lines lies in their ability to elucidate the role of the NARF gene in various biological contexts. By studying these knockout models, researchers can gain insights into the gene's contribution to cellular homeostasis, disease mechanisms, and therapeutic responses. The knockout mechanism is achieved using sophisticated gene-editing technologies, such as CRISPR/Cas9, ensuring accurate gene targeting and reproducibility across different experiments.
The scientific importance of these cell lines cannot be overstated. They serve as an invaluable resource for investigating conditions like metabolic disorders, cancer biology, and neurodegenerative diseases. In clinical research settings, NARF knockout models can pave the way for developing novel therapeutic strategies and drugs by providing a platform for high-throughput screening and validation of potential treatments.
Compared to traditional models, NARF Gene Knockout Cell Lines offer distinct advantages such as enhanced specificity and reduced off-target effects. The precision of the genetic modifications enables researchers to draw more reliable conclusions about gene function and related pathways. Furthermore, our cell lines come validated and characterized, simplifying the research process and ensuring robust results.
For researchers, clinicians, and biopharma professionals, investing in NARF Gene Knockout Cell Lines represents a strategic advantage. Their ability to facilitate novel discoveries in gene function positions them as essential tools in the rapidly evolving field of molecular biology.
As a leader in developing cutting-edge biological products, our company is committed to delivering high-quality resources coupled with expert support to advance your research objectives and enhance your scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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