Gene: NAIP
Official Full Name: NLR family apoptosis inhibitory proteinprovided by HGNC
Gene Summary: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36477 | NAIP Knockout cell line (HeLa) | Human | NAIP | 1:3~1:6 | Negative | Online Inquiry |
KO36478 | NAIP Knockout cell line (HCT 116) | Human | NAIP | 1:2~1:4 | Negative | Online Inquiry |
KO36479 | NAIP Knockout cell line (A549) | Human | NAIP | 1:3~1:4 | Negative | Online Inquiry |
NAIP Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the investigation of neuronal apoptosis inhibitory protein (NAIP) functions in both physiological and pathological contexts. These knockout cell lines have been generated using state-of-the-art CRISPR-Cas9 technology to precisely disrupt the NAIP gene, allowing for a deeper exploration of its role in regulating immune responses and neuronal health.
The primary function of NAIP proteins lies in their involvement in the recognition of pathogens and modulation of inflammatory processes. By impairing the NAIP gene, researchers can elucidate how these proteins contribute to neurodegenerative diseases and innate immunity. The mechanistic insights gained from these cell lines enable scientists to dissect signaling pathways, assess cellular responses to infections, and identify therapeutic targets for conditions such as spinal muscular atrophy and other neuroinflammatory disorders.
The scientific significance of NAIP Gene Knockout Cell Lines extends to various research and clinical applications, offering invaluable tools for studying disease mechanisms, drug development, and potential gene therapy strategies. Compared to other available models, these knockout cell lines provide a more precise and reliable system for investigating the role of NAIP in human health, thanks to their targeted gene modification, which minimizes off-target effects commonly associated with earlier knockout methodologies.
Furthermore, these cell lines are exceptionally valuable for researchers and clinicians seeking to advance their understanding of NAIP-related disorders. By offering a reproducible and consistent model, they enhance experimental rigor and facilitate the translation of findings from bench to bedside.
Our company is committed to empowering the scientific community with high-quality biological products. With a focus on innovation and precision, we ensure that our offerings, such as the NAIP Gene Knockout Cell Lines, meet the highest standards of scientific integrity, reliability, and relevance in research.
Please note that all services are for research use only. Not intended for any clinical use.
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