Gene: MYRF
Official Full Name: myelin regulatory factorprovided by HGNC
Gene Summary: This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09628 | MYRF Knockout cell line (HeLa) | Human | MYRF | 1:3~1:6 | Negative | Online Inquiry |
KO09629 | MYRF Knockout cell line (HCT 116) | Human | MYRF | 1:2~1:4 | Negative | Online Inquiry |
KO09630 | MYRF Knockout cell line (HEK293) | Human | MYRF | 1:3~1:6 | Negative | Online Inquiry |
KO09631 | MYRF Knockout cell line (A549) | Human | MYRF | 1:3~1:4 | Negative | Online Inquiry |
MYRF Gene Knockout Cell Lines represent a pivotal advancement in genetic research and therapeutic development. These specialized cell lines have been engineered to create a knockout of the MYRF gene, which encodes the myelin regulatory factor, a crucial transcription factor involved in myelination and the development of oligodendrocytes in the central nervous system. By systematically disrupting the MYRF gene, these cell lines provide an essential tool for dissecting the molecular pathways that underpin myelination and neurodegenerative diseases.
The primary function of MYRF Knockout Cell Lines is to facilitate the investigation of gene function and expression patterns associated with MYRF deficiency. The removal of this gene allows researchers to explore altered cellular processes, including differentiation, proliferation, and signal transduction pathways, crucial for understanding diseases like multiple sclerosis and other demyelinating disorders. Researchers can utilize these cell lines in various applications, including drug discovery, gene therapy, and the testing of therapeutic compounds aimed at restoring myelin integrity.
One of the key advantages of our MYRF Gene Knockout Cell Lines is the precision with which the knockout has been achieved. Unlike traditional methods of gene disruption, such as chemical mutagenesis or random insertion, our targeted CRISPR-Cas9 gene-editing technology ensures specific and reproducible gene removal, allowing for consistent experimental results. Moreover, these cell lines are validated for consistent performance in both in vitro and in vivo models, offering researchers the reliability needed for rigorous scientific inquiry.
The importance of these cell lines extends beyond basic research; they are poised to unlock new avenues for clinical applications related to regenerative medicine and the treatment of neuronal disorders. By creating a clear link between the MYRF gene and cellular phenotypes, researchers can pave the way for innovative therapeutic strategies that address unmet medical needs.
In conclusion, our MYRF Gene Knockout Cell Lines represent a significant asset to the research community, driving forward the understanding of myelin biology and related pathologies. With our commitment to scientific excellence and innovation, our company remains at the forefront of providing high-quality biological products that empower researchers and clinicians to make pioneering discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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