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MYOF Knockout Cell Lines

Gene: MYOF

Official Full Name: myoferlinprovided by HGNC

Gene Summary: Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined. [provided by RefSeq, Dec 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28085 MYOF Knockout cell line (HeLa) Human MYOF 1:3~1:6 Negative Online Inquiry
KO28086 MYOF Knockout cell line (HCT 116) Human MYOF 1:2~1:4 Negative Online Inquiry
KO28087 MYOF Knockout cell line (HEK293) Human MYOF 1:3~1:6 Negative Online Inquiry
KO28088 MYOF Knockout cell line (A549) Human MYOF 1:3~1:4 Negative Online Inquiry

Background

MYOF Gene Knockout Cell Lines are specialized cellular models engineered to impair the expression of the MYOF gene, which encodes the myoferlin protein involved in critical cellular processes such as membrane repair, cell differentiation, and muscle physiology. These cell lines are created using state-of-the-art CRISPR-Cas9 gene editing technology, providing researchers with a precise and efficient means to study the functional consequences of MYOF loss in both physiological and pathological contexts.

The primary function of MYOF Gene Knockout Cell Lines is to facilitate in-depth investigations into the role of myoferlin in various cellular mechanisms and disease models. By silencing the MYOF gene, researchers can assess alterations in cellular morphology, membrane integrity, and signaling pathways responsive to injury or stress. This makes the cell lines particularly valuable for studies focused on muscular dystrophy, cancer, and regenerative medicine.

In research and clinical applications, the significance of MYOF gene knockout models extends to their contribution to understanding the pathogenesis of muscle-related disorders and other conditions linked to cellular membrane dynamics. These models can serve as a foundation for screening potential therapeutic agents or exploring the effects of genetic interventions, paving the way for innovative treatment strategies.

Unlike traditional cell models, MYOF Gene Knockout Cell Lines offer several advantages. Their precise gene editing allows for a controlled environment to study myoferlin's role without the variability associated with spontaneous mutations or compensatory gene expression. Furthermore, these cell lines can be used in high-throughput screening applications, enabling rapid assessments of drug efficacy and mechanistic studies.

For researchers and clinicians, investing in MYOF Gene Knockout Cell Lines means gaining access to a powerful tool capable of unraveling complex biological questions and advancing therapeutic options. Our company is dedicated to enhancing scientific exploration with high-quality, rigorously tested biological products, and the MYOF Gene Knockout Cell Lines exemplify this commitment to excellence in life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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