Gene: MYO9B
Official Full Name: myosin IXBprovided by HGNC
Gene Summary: This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09721 | MYO9B Knockout cell line (HeLa) | Human | MYO9B | 1:3~1:6 | Negative | Online Inquiry |
KO09722 | MYO9B Knockout cell line (HCT 116) | Human | MYO9B | 1:2~1:4 | Negative | Online Inquiry |
KO09723 | MYO9B Knockout cell line (HEK293) | Human | MYO9B | 1:3~1:6 | Negative | Online Inquiry |
KO09724 | MYO9B Knockout cell line (A549) | Human | MYO9B | 1:3~1:4 | Negative | Online Inquiry |
MYO9B Gene Knockout Cell Lines are a specialized tool in molecular biology that facilitates the study of the MYO9B gene, a member of the myosin superfamily implicated in various cellular processes, including cell motility and signal transduction. These cell lines have been genetically engineered to disrupt the MYO9B gene, enabling researchers to investigate the functional consequences of MYO9B loss in a controlled environment. This innovative product is essential for elucidating the gene's role in pathophysiological conditions and understanding its impact on cellular dynamics.
The knockout mechanism involves CRISPR-Cas9 or similar genome editing technologies, which introduce precise mutations or deletions in the MYO9B locus. As a result, researchers can observe alterations in cellular behaviors, such as adhesion, migration, and intracellular signaling pathways, providing insights into the underlying mechanisms of diseases associated with MYO9B dysfunction.
In clinical and research settings, MYO9B Gene Knockout Cell Lines are invaluable for drug discovery, functional genomics studies, and the development of potential therapeutic interventions. By studying how the absence of MYO9B influences cellular responses, researchers can identify novel drug targets and biomolecular pathways that may contribute to more effective treatments for related conditions, such as cancer or cardiovascular diseases.
Compared to alternative models, the MYO9B Gene Knockout Cell Lines offer specific advantages, including high specificity in gene alteration and reproducibility of experimental results. The ability to utilize these knockout lines in various experimental formats enhances their versatility and applicability in both basic and applied research.
For researchers and clinicians focused on the intricacies of gene function and its implications in health and disease, MYO9B Gene Knockout Cell Lines represent an essential component of their toolkit. The potential for innovative discoveries stemming from their use is significant, making them a crucial asset for advancing scientific knowledge.
Our company prides itself on its expertise in providing high-quality, genetically modified cell lines tailored to meet the needs of the research community. We are committed to advancing scientific research by offering products that facilitate groundbreaking discoveries in biology and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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