Gene: MYLK3
Official Full Name: myosin light chain kinase 3provided by HGNC
Gene Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08435 | MYLK3 Knockout cell line (HeLa) | Human | MYLK3 | 1:3~1:6 | Negative | Online Inquiry |
MYLK3 Gene Knockout Cell Lines are advanced biological models engineered to facilitate the study of the Myosin Light Chain Kinase 3 (MYLK3) gene, which plays a pivotal role in muscle contraction and cellular signaling pathways. These cell lines are generated using state-of-the-art CRISPR-Cas9 technology, resulting in precise deletions or modifications of the MYLK3 gene, allowing researchers to investigate its biological functions in a controlled environment.
The primary function of the MYLK3 Gene Knockout Cell Lines lies in their ability to model conditions resulting from MYLK3 deficiency, enabling the dissection of its contributions to various cellular mechanisms, such as contraction strength, cellular migration, and inflammatory responses. The knockout of MYLK3 leads to significant alterations in signaling pathways, providing valuable insights into diseases where this gene is implicated, including cardiovascular disorders and certain cancers.
Scientifically, these cell lines have immense importance in both research and clinical applications. They serve as critical tools for studying the pathophysiology of diseases related to improper MYLK3 activation and help in the development of targeted therapies. By using these models, researchers can screen potential pharmacological agents, evaluate therapeutic efficacy, and dissect molecular pathways critical to muscle-specific functions and overall cellular health.
One significant advantage of the MYLK3 Gene Knockout Cell Lines over traditional models is the specificity and efficiency of the knockout mechanism. While other methods may introduce off-target effects or fail to achieve complete gene disruption, our CRISPR-engineered cell lines ensure high fidelity and reproducibility in research outcomes. This specificity allows for more accurate modeling of diseases, which is crucial for translational research.
For researchers and clinicians, utilizing MYLK3 Gene Knockout Cell Lines provides a reliable platform for hypothesis-driven research and drug discovery. The ability to observe the effects of MYLK3 loss in real-time enhances experimental designs, leading to novel insights and potential breakthroughs in understanding and treating MYLK3-associated pathologies.
With a commitment to innovation and excellence, our company prides itself on providing high-quality biological research tools, such as the MYLK3 Gene Knockout Cell Lines, backed by expertise in genetic engineering and cell biology, ensuring that our products meet the rigorous standards expected by the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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