Gene: MTMR8
Official Full Name: myotubularin related protein 8provided by HGNC
Gene Summary: This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases. [provided by RefSeq, Mar 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07867 | MTMR8 Knockout cell line (HeLa) | Human | MTMR8 | 1:3~1:6 | Negative | Online Inquiry |
KO07868 | MTMR8 Knockout cell line (HCT 116) | Human | MTMR8 | 1:2~1:4 | Negative | Online Inquiry |
KO07869 | MTMR8 Knockout cell line (HEK293) | Human | MTMR8 | 1:3~1:6 | Negative | Online Inquiry |
KO07870 | MTMR8 Knockout cell line (A549) | Human | MTMR8 | 1:3~1:4 | Negative | Online Inquiry |
MTMR8 Gene Knockout Cell Lines refer to genetically engineered cellular models in which the MTMR8 gene—the gene encoding the protein myotubularin related protein 8—has been disrupted or "knocked out." These cell lines serve as essential tools for studying the biological functions and pathways associated with MTMR8, particularly its role in cellular processes such as endocytosis, membrane trafficking, and the regulation of lipid metabolism. By enabling researchers to investigate the effects of MTMR8 depletion, these knockout lines facilitate a deeper understanding of associated pathologies, including neuromuscular diseases and certain types of cancer.
The functionality of the MTMR8 Gene Knockout Cell Lines lies in their ability to recapitulate the physiological conditions observed in disease scenarios. By using CRISPR/Cas9 gene-editing technology, these cell lines provide a controlled environment in which the consequences of MTMR8 loss can be meticulously examined. This includes assessing alterations in cell morphology, migration, and growth patterns, as well as changes in signaling pathways that may impact cell survival and differentiation.
Scientifically, MTMR8 knockout models are invaluable for elucidating the gene's role in health and disease, offering insights that could lead to novel therapeutic approaches. In clinical research, they can aid in the identification of biomarkers for disease progression and treatment responsiveness, thereby enhancing personalized medicine strategies.
Distinctively, the MTMR8 Gene Knockout Cell Lines stand out from conventional wild-type cell lines as they specifically enable the exploration of the gene's loss-of-function effects, providing nuanced datasets that highlight the importance of MTMR8 in developmental and pathological contexts. Researchers will find these cell lines beneficial as they minimize ambiguity in experimental results that could arise from compensatory mechanisms present in wild-type systems.
By investing in MTMR8 Gene Knockout Cell Lines, researchers, and clinicians gain access to robust models that support high-quality, reproducible scientific inquiries. Our company specializes in the production of genetically modified cell lines, leveraging cutting-edge technologies and expertise to deliver products that empower the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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