Gene: MTERF1
Official Full Name: mitochondrial transcription termination factor 1provided by HGNC
Gene Summary: This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34370 | MTERF1 Knockout cell line (HeLa) | Human | MTERF1 | 1:3~1:6 | Negative | Online Inquiry |
KO34371 | MTERF1 Knockout cell line (HCT 116) | Human | MTERF1 | 1:2~1:4 | Negative | Online Inquiry |
KO34372 | MTERF1 Knockout cell line (HEK293) | Human | MTERF1 | 1:3~1:6 | Negative | Online Inquiry |
KO34373 | MTERF1 Knockout cell line (A549) | Human | MTERF1 | 1:3~1:4 | Negative | Online Inquiry |
MTERF1 Gene Knockout Cell Lines are genetically engineered models designed to investigate the role of the MTERF1 gene in various biological processes. MTERF1, or Mitochondrial Transcription Termination Factor 1, plays a crucial role in mitochondrial gene expression and is implicated in the regulation of mitochondrial ribosome assembly, thereby influencing mitochondrial function and cellular metabolism. The knockout cell lines provide an invaluable tool for researchers to explore the pathway dynamics and functional implications of MTERF1 in both healthy and pathological states.
These cell lines function by employing CRISPR-Cas9 or similar gene-editing technologies to effectively disrupt the MTERF1 gene, allowing researchers to assess the phenotypic consequences of its loss. These models enable detailed studies into mitochondrial dysfunctions linked to diseases such as neurodegenerative conditions, metabolic syndromes, and certain types of cancer, thus facilitating a deeper understanding of the molecular mechanisms underlying these health issues.
From a scientific perspective, the MTERF1 Gene Knockout Cell Lines offer key applications in drug screening, gene functionality assays, and the development of novel therapeutic interventions. The unique advantage of using these knockout models lies in their ability to mimic human disease states more accurately than traditional cell lines, thereby providing more relevant data and insights into disease mechanisms and potential treatments.
For researchers and clinicians, these cell lines represent a robust platform for advancing biomedical research, allowing for reproducible and reliable studies that can contribute to translational applications. Their specificity and adaptability make them an essential resource for those looking to pioneer solutions in mitochondrial biology and associated therapeutic fields.
Backed by our company’s extensive experience in genetic engineering and a commitment to quality, we offer MTERF1 Gene Knockout Cell Lines as part of our portfolio of innovative biological products, designed to empower researchers in their quest for scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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