Gene: MTCH2
Official Full Name: mitochondrial carrier 2provided by HGNC
Gene Summary: This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO06752 | MTCH2 Knockout cell line (HeLa) | Human | MTCH2 | 1:3~1:6 | Negative | Online Inquiry |
KO06753 | MTCH2 Knockout cell line (HCT 116) | Human | MTCH2 | 1:2~1:4 | Negative | Online Inquiry |
KO06754 | MTCH2 Knockout cell line (HEK293) | Human | MTCH2 | 1:3~1:6 | Negative | Online Inquiry |
KO06755 | MTCH2 Knockout cell line (A549) | Human | MTCH2 | 1:3~1:4 | Negative | Online Inquiry |
MTCH2 Gene Knockout Cell Lines are a specialized biological tool designed for researchers investigating the functions and pathways associated with the MTCH2 gene. These cell lines are genetically modified to exhibit a complete knockout of the MTCH2 gene, allowing for the assessment of its role in cellular processes such as apoptosis, cellular metabolism, and mitochondrial dynamics. By eliminating the expression of MTCH2, these cell lines serve as a critical resource for elucidating the consequences of MTCH2 deficiency on various cellular mechanisms.
The primary function of MTCH2 Gene Knockout Cell Lines is to facilitate studies on the mechanistic pathways affected by the absence of this gene. MTCH2 has been identified as a pivotal player in mitochondrial function and energy metabolism; hence, these knockout cell lines can be utilized to investigate how the disruption of its expression alters mitochondrial morphology and function, affecting overall cellular health. This elucidation is significant for understanding diseases linked to mitochondrial dysfunction, such as metabolic syndromes or neurodegenerative disorders.
In research and clinical settings, these cell lines are extremely valuable for drug discovery, therapeutic target validation, and functional genomics studies. They allow researchers to model disease states in vitro, providing insights that could lead to novel interventions. Compared to conventional wild-type cell lines, MTCH2 Knockout Cell Lines present a unique advantage by eliminating the variability introduced by normal gene expression, thereby enabling more robust and reproducible experimental results.
Researchers and clinicians can capitalize on these specialized cell lines to obtain data that rigorously defines the role of MTCH2 in health and disease. This targeted approach not only enhances the efficiency of research but also accelerates the translation of findings into clinical applications.
At [Your Company Name], we are committed to advancing scientific research through high-quality biological products. Our expertise in genetic engineering and cell line development ensures that our MTCH2 Gene Knockout Cell Lines meet the highest standards in the field, alongside comprehensive support for users to maximize their experimental outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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