Gene: MSX2
Official Full Name: msh homeobox 2provided by HGNC
Gene Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04459 | MSX2 Knockout cell line (HeLa) | Human | MSX2 | 1:3~1:6 | Negative | Online Inquiry |
KO04460 | MSX2 Knockout cell line (HCT 116) | Human | MSX2 | 1:2~1:4 | Negative | Online Inquiry |
KO04461 | MSX2 Knockout cell line (HEK293) | Human | MSX2 | 1:3~1:6 | Negative | Online Inquiry |
KO04462 | MSX2 Knockout cell line (A549) | Human | MSX2 | 1:3~1:4 | Negative | Online Inquiry |
MSX2 Gene Knockout Cell Lines are genetically engineered cell lines in which the MSX2 gene, known for its crucial role in developmental processes and cell differentiation, has been completely disrupted. These knockout cell lines provide a powerful tool for researchers to investigate the specific functions of the MSX2 gene and its implications in various biological processes, such as bone and cartilage development, and its involvement in pathologies like craniosynostosis and tumors.
Functionally, the MSX2 gene encodes a transcription factor that regulates gene expression during embryonic development. By knocking out this gene, users can study the resultant phenotypic changes and cellular behavior in a controlled environment, allowing for a deeper understanding of gene function in lineage commitment and morphogenesis. The unique cellular responses observed in these knockout lines can elucidate MSX2's role in cellular signaling pathways, providing insights that are valuable for both basic research and therapeutic development.
The scientific importance of MSX2 Gene Knockout Cell Lines extends to their applications in drug discovery and gene therapy research, where understanding genetic influences can lead to potential treatment strategies. Clinically, these cell lines are essential for modeling diseases associated with MSX2 dysregulation, thereby facilitating the development of targeted interventions.
Compared to other genetic models, these knockout cell lines offer superior specificity and reliability in studying gene function, without the confounding influences of wild-type alleles. By utilizing robust techniques such as CRISPR-Cas9 for gene editing, our cell lines ensure a high level of precision, reducing variability in experimental outcomes.
For researchers and clinicians alike, the MSX2 Gene Knockout Cell Lines represent an invaluable resource for advancing the understanding of gene function and its implications in health and disease. Our company, with its expertise in molecular biology and genetic engineering, is committed to providing high-quality biological products that empower scientific discovery and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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