Gene: MSRB1
Official Full Name: methionine sulfoxide reductase B1provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22233 | MSRB1 Knockout cell line (HeLa) | Human | MSRB1 | 1:3~1:6 | Negative | Online Inquiry |
KO22234 | MSRB1 Knockout cell line (HCT 116) | Human | MSRB1 | 1:2~1:4 | Negative | Online Inquiry |
KO22235 | MSRB1 Knockout cell line (HEK293) | Human | MSRB1 | 1:3~1:6 | Negative | Online Inquiry |
KO22236 | MSRB1 Knockout cell line (A549) | Human | MSRB1 | 1:3~1:4 | Negative | Online Inquiry |
MSRB1 Gene Knockout Cell Lines are a specialized tool designed for the study of biological processes associated with the methionine sulfoxide reductase B1 (MSRB1) gene, which is critically involved in cellular responses to oxidative stress and regulation of inflammatory pathways. This product offers a model system where the MSRB1 gene is specifically inactivated, allowing researchers to investigate the functional role of MSRB1 in various cellular contexts.
The key mechanism by which these knockout cell lines operate is through the precise deletion of the MSRB1 gene, achieved using advanced gene-editing techniques such as CRISPR/Cas9. By eliminating the gene's expression, scientists can elucidate the pathways influenced by MSRB1, including its role in redox homeostasis and protein repair under oxidative conditions. This insight can further our understanding of various diseases where oxidative stress and inflammation are critical factors, such as neurodegenerative disorders, cardiovascular diseases, and certain cancers.
The scientific importance of MSRB1 Gene Knockout Cell Lines is immense, as they provide a robust model for understanding the mechanistic underpinnings of diseases and for drug discovery efforts. In clinical settings, these cell lines can be utilized to screen potential therapeutic agents targeting oxidative stress pathways, thereby contributing to the development of novel interventions for various conditions linked to MSRB1 activity.
Compared to conventional cell lines, MSRB1 knockout models offer distinct advantages, including specific insights into the gene's function and its absence’s impact on cellular biochemistry. This specificity aids researchers in generating consistent and reproducible data, facilitating a deeper understanding of the gene's involvement in health and disease.
For researchers and clinicians, the MSRB1 Gene Knockout Cell Lines present a valuable resource for advancing knowledge in cellular biology, contributing to innovative therapeutic strategies, and ultimately improving patient outcomes. With deep expertise in molecular biology, our company ensures that these cell lines are rigorously validated and meet the highest standards, empowering researchers in their quest for scientific breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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