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MRPS28 Knockout Cell Lines

Gene: MRPS28

Official Full Name: mitochondrial ribosomal protein S28provided by HGNC

Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05088 MRPS28 Knockout cell line (HeLa) Human MRPS28 1:3~1:6 Negative Online Inquiry
KO05089 MRPS28 Knockout cell line (HCT 116) Human MRPS28 1:2~1:4 Negative Online Inquiry
KO05090 MRPS28 Knockout cell line (HEK293) Human MRPS28 1:3~1:6 Negative Online Inquiry
KO05091 MRPS28 Knockout cell line (A549) Human MRPS28 1:3~1:4 Negative Online Inquiry

Background

MRPS28 Gene Knockout Cell Lines are meticulously engineered human cell lines in which the MRPS28 gene has been deleted or silenced, allowing for in-depth studies on mitochondrial ribosome functionality and its implications in human health and disease. MRPS28 encodes a protein that is integral to mitochondrial translation processes, making these knockout models critical for understanding the role of mitochondrial dysfunction in various pathologies, including neurodegenerative disorders, metabolic syndromes, and certain types of cancer.

The key function of MRPS28 Gene Knockout Cell Lines lies in their ability to mimic the effects of MRPS28 deficiency, thereby enabling researchers to investigate the downstream consequences on mitochondrial protein synthesis, bioenergetics, and overall cellular metabolism. This innovative model provides a unique platform to explore the role of mitochondrial ribosomes in translation accuracy and efficiency, as well as their impact on mitochondrial gene expression regulation.

Scientifically, these knockout cell lines are invaluable tools in both basic and applied research. They facilitate the exploration of mitochondrial involvement in human diseases and the potential for targeted therapies. In the clinical setting, such models can also play a pivotal role in drug development and precision medicine, as they allow scientists to assess the therapeutic efficacy of compounds aimed at restoring mitochondrial function.

What sets MRPS28 Gene Knockout Cell Lines apart from other genetic models is their precise targeting and validation, ensuring reliable and reproducible results. Unlike standard cell lines that may have varying expression levels of MRPS28, these knockout lines provide a singular focus on the absence of the MRPS28 gene, allowing for clear insights into the specific roles this gene plays.

For researchers and clinicians eager to advance their work on mitochondrial biology and associated diseases, MRPS28 Gene Knockout Cell Lines represent a significant advancement. The robustness of these models, along with our company's commitment to quality and innovation in biological products, makes this offering an essential component of any researcher's toolkit. Through our expertise in genetic engineering and cell line development, we provide exceptional resources that further scientific understanding and therapeutic discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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