Gene: MRPL55
Official Full Name: mitochondrial ribosomal protein L55provided by HGNC
Gene Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26779 | MRPL55 Knockout cell line (HeLa) | Human | MRPL55 | 1:3~1:6 | Negative | Online Inquiry |
KO26780 | MRPL55 Knockout cell line (HCT 116) | Human | MRPL55 | 1:2~1:4 | Negative | Online Inquiry |
KO26781 | MRPL55 Knockout cell line (HEK293) | Human | MRPL55 | 1:3~1:6 | Negative | Online Inquiry |
MRPL55 Gene Knockout Cell Lines are genetically engineered human or mammalian cell lines specifically altered to lack the expression of the MRPL55 gene, which encodes a mitochondrial ribosomal protein vital for mitochondrial protein synthesis. These cell lines serve as powerful tools in biological research, allowing scientists to investigate the functional consequences of MRPL55 deficiency on cellular metabolism, proliferation, and apoptosis.
The primary mechanism of action involves the disruption of mitochondrial translation processes, leading to impaired mitochondrial function. This can significantly affect energy production, reactive oxygen species (ROS) regulation, and overall cellular health. Consequently, MRPL55 knockout cells provide insights into diseases associated with mitochondrial dysfunction, including neurodegenerative disorders and certain forms of cancer.
In research and clinical settings, MRPL55 Gene Knockout Cell Lines play a critical role in the identification and characterization of potential therapeutic targets, screening for drug candidates, and elucidating the molecular underpinnings of various diseases. By using these cell lines, researchers can develop more effective treatment strategies and study the therapeutic implications of restoring mitochondrial functions.
What distinguishes our MRPL55 Gene Knockout Cell Lines from alternative products is our commitment to ensuring high fidelity in genetic modifications, combined with rigorous quality control processes. Each cell line undergoes comprehensive validation to confirm the knockout and assess phenotypic changes, thereby providing reliable and reproducible results for researchers.
These knockout cell lines are invaluable assets for researchers and clinicians striving to advance the understanding of mitochondrial biology and develop innovative treatment options. Our expertise in genetic engineering and cell line development ensures that you are equipped with reliable tools to accelerate your research goals.
Please note that all services are for research use only. Not intended for any clinical use.
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