Gene: MRC2
Official Full Name: mannose receptor C-type 2provided by HGNC
Gene Summary: This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05330 | MRC2 Knockout cell line (HeLa) | Human | MRC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05331 | MRC2 Knockout cell line (HCT 116) | Human | MRC2 | 1:2~1:4 | Negative | Online Inquiry |
KO05332 | MRC2 Knockout cell line (HEK293) | Human | MRC2 | 1:3~1:6 | Negative | Online Inquiry |
KO05333 | MRC2 Knockout cell line (A549) | Human | MRC2 | 1:3~1:4 | Negative | Online Inquiry |
MRC2 Gene Knockout Cell Lines are genetically modified cell lines that have been engineered to lack the expression of the MRC2 gene, which encodes for a membrane protein known as the mannose receptor C-type 2. This alteration allows researchers to explore the physiological and biochemical roles of MRC2 in various biological processes, including immune response, cellular signaling, and tissue remodeling.
The key function of MRC2 Gene Knockout Cell Lines lies in their ability to serve as a model for studying the functional consequences of MRC2 deficiency. By observing cellular behavior and response during experimental manipulations, researchers can elucidate the pathway interactions and physiological impacts of this receptor, leading to a deeper understanding of its role in health and disease. The knockout feature enables the analysis of gene function through loss-of-function studies, providing critical insights into various cellular mechanisms.
Scientifically, these cell lines hold significant importance for applications in both basic and applied research settings, particularly in fields such as immunology, cancer biology, and tissue engineering. Researchers can leverage the MRC2 knockout model to investigate the receptor's potential contributions to tumor progression or immune evasion in cancers, explore its role in pathogen recognition and clearance, and study its involvement in macrophage activation and function.
One of the unique selling points of MRC2 Gene Knockout Cell Lines is their specificity and reliability. Unlike other genetic models that may exhibit variable gene editing efficiency, these cell lines come with validated loss-of-function status and characterized phenotypes, ensuring reproducibility in experimental outcomes. Additionally, their ease of use in standard laboratory protocols makes them highly accessible for a wide range of experiments.
For researchers and clinicians aiming to streamline their investigations into the complexities of immune regulation and disease models, MRC2 Gene Knockout Cell Lines offer a robust tool. The value they provide is underscored by the opportunity to generate impactful data that can lead to advancements in therapeutic strategies and a clearer understanding of disease mechanisms.
As an industry leader, our company specializes in the development of high-quality biological products, ensuring that our offerings, such as the MRC2 Gene Knockout Cell Lines, meet the highest standards of scientific rigor and quality control, empowering researchers to drive innovation in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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