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MOCS1 Knockout Cell Lines

Gene: MOCS1

Official Full Name: molybdenum cofactor synthesis 1provided by HGNC

Gene Summary: Molybdenum cofactor biosynthesis is a conserved pathway leading to the biological activation of molybdenum. The protein encoded by this gene is involved in this pathway. This gene was originally thought to produce a bicistronic mRNA with the potential to produce two proteins (MOCS1A and MOCS1B) from adjacent open reading frames. However, only the first open reading frame (MOCS1A) has been found to encode a protein from the putative bicistronic mRNA, whereas additional splice variants are likely to produce a fusion between the two open reading frames. This gene is defective in patients with molybdenum cofactor deficiency, type A. A related pseudogene has been identified on chromosome 16. [provided by RefSeq, Nov 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36588 MOCS1 Knockout cell line (HCT 116) Human MOCS1 1:2~1:4 Negative Online Inquiry
KO36589 MOCS1 Knockout cell line (HEK293) Human MOCS1 1:3~1:6 Negative Online Inquiry
KO36590 MOCS1 Knockout cell line (A549) Human MOCS1 1:3~1:4 Negative Online Inquiry

Background

MOCS1 Gene Knockout Cell Lines are genetically modified cell lines developed to study the functions and pathways regulated by the MOCS1 gene, which is critically involved in the biosynthesis of molybdenum cofactor. These knockout cell lines effectively disable the MOCS1 gene, providing an essential tool for researchers to explore the resultant phenotypic changes and metabolic disruptions that arise from the loss of this gene.

The key function of MOCS1 involves the synthesis of molybdenum cofactor, which is vital for the activity of various enzymes, including sulfite oxidase and xanthine dehydrogenase. By utilizing these knockout cell lines, researchers can elucidate the downstream effects of impaired molybdenum cofactor production, revealing insights into metabolic pathways associated with sulfite and purine metabolism. This is particularly significant for understanding diseases related to genetic mutations in MOCS1, such as molybdenum cofactor deficiency, which can lead to severe neurological disorders.

The scientific importance of MOCS1 Gene Knockout Cell Lines lies in their versatility in both basic research and clinical applications. They serve as an invaluable model for studying neurological development and metabolic dysfunctions, thereby aiding in the identification of potential pharmacological targets for therapeutic intervention.

What sets these cell lines apart is their rigorous validation and reliability in experimental settings. Compared to traditional models, MOCS1 knockout lines allow for the specific investigation of gene function without confounding factors, ensuring that researchers can obtain reproducible and clear results. The ease of use and adaptability in various assay formats further enhance their value.

Researchers and clinicians will find significant value in utilizing MOCS1 Gene Knockout Cell Lines due to their ability to deepen our understanding of gene function in health and disease. The insights gained can foster developments in gene therapy strategies and targeted treatments for conditions arising from MOCS1 deficiencies.

Our company specializes in providing high-quality biological products, including genetically modified cell lines, backed by extensive expertise in molecular biology and genetics. We are dedicated to advancing research and therapeutic possibilities by delivering reliable and innovative tools to the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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