Gene: MMP24
Official Full Name: matrix metallopeptidase 24provided by HGNC
Gene Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31441 | MMP24 Knockout cell line (A549) | Human | MMP24 | 1:3~1:4 | Negative | Online Inquiry |
MMP24 Gene Knockout Cell Lines are genetically engineered cellular models designed to lack the expression of the matrix metalloproteinase 24 (MMP24) gene, a critical component involved in extracellular matrix remodeling and tissue regeneration processes. These cell lines serve as a powerful tool for researchers to dissect the role of MMP24 in various biological contexts, including cancer progression, inflammation, and wound healing.
The primary mechanisms of MMP24 involve the degradation of extracellular matrix components, facilitating cellular migration and adhesion. In normal physiology, MMP24 is transiently expressed during processes such as embryogenesis and tissue repair. However, aberrant expression of this enzyme has been linked to pathological conditions, including tumors and fibrosis. By utilizing MMP24 Gene Knockout Cell Lines, researchers can effectively study the downstream signaling pathways and biological consequences of MMP24 deficiency, leading to a deeper understanding of its functional implications in health and disease.
The scientific importance of these knockout cell lines extends across multiple research disciplines, making them invaluable for both fundamental and applied scientific inquiries. In clinical settings, understanding MMP24's role can inform the development of targeted therapies, particularly in oncology and regenerative medicine. Furthermore, these models ease the exploration of gene function, offering researchers a clear advantage over traditional methods that may not adequately represent the gene's role.
Compared to alternative models, MMP24 Gene Knockout Cell Lines offer distinct advantages, including precise gene targeting, consistent phenotypic outcomes, and the ability to create stable expressions of other molecular constructs in the same background. This unique capability allows for streamlined experimental designs, providing insights that would be challenging to obtain with wild-type cell lines.
For researchers, clinicians, and biopharmaceutical companies, the value of MMP24 Gene Knockout Cell Lines lies in their robustness and reliability as a research platform. They not only enhance the understanding of matrix metalloproteinases' roles in disease but also accelerate advancements in therapeutic discovery. At [Your Company Name], we leverage cutting-edge genetic engineering techniques and deep expertise in cell line development, ensuring that our MMP24 Gene Knockout Cell Lines meet the highest standards of quality, reproducibility, and utility in scientific research.
Please note that all services are for research use only. Not intended for any clinical use.
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