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MIEF2 Knockout Cell Lines

Gene: MIEF2

Official Full Name: mitochondrial elongation factor 2provided by HGNC

Gene Summary: This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27646 MIEF2 Knockout cell line (HeLa) Human MIEF2 1:3~1:6 Negative Online Inquiry
KO27647 MIEF2 Knockout cell line (HCT 116) Human MIEF2 1:2~1:4 Negative Online Inquiry
KO27648 MIEF2 Knockout cell line (HEK293) Human MIEF2 1:3~1:6 Negative Online Inquiry
KO27649 MIEF2 Knockout cell line (A549) Human MIEF2 1:3~1:4 Negative Online Inquiry

Background

MIEF2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of MIEF2 (Mitochondrial Elongation Factor 2). This critical gene plays a vital role in mitochondrial dynamics, influencing processes such as membrane fusion and fission. By removing MIEF2, researchers can observe the resulting phenotypic and functional changes, allowing for a better understanding of mitochondrial physiology and its implications for various diseases.

The primary function of the MIEF2 Gene Knockout Cell Lines is to serve as a model for studying mitochondrial dysfunction and related pathologies, including neurodegenerative diseases, metabolic disorders, and cancer. The knockout mechanism, achieved through advanced CRISPR/Cas9 technology, ensures precise deletion of the MIEF2 gene, thereby enabling scientists to investigate compensatory pathways, metabolic shifts, and the mitochondrial role in cellular health.

The scientific importance of these cell lines lies in their application potential in both research and clinical settings. Researchers can leverage these knockout models to explore mitochondrial behavior, cellular stress responses, and the underlying mechanisms of diseases characterized by altered mitochondrial dynamics. This can facilitate the development of targeted therapies aimed at restoring mitochondrial function or mitigating disease progression.

A significant advantage of our MIEF2 Gene Knockout Cell Lines is the specificity and reliability associated with their creation. Unlike transient knockdown methods, these stable knockouts provide enduring models that maintain the genetic alterations over numerous passages, thus ensuring reproducibility in experimental outcomes. Additionally, our cell lines are extensively validated for functionality and uniformity, offering researchers confidence in their experimental design.

For researchers and clinicians alike, these knockout cell lines open avenues for innovative discoveries in mitochondrial biology and the therapeutic interventions targeting mitochondrial dysfunction. Now more than ever, understanding the roles of genes like MIEF2 is pivotal in the realm of biomedicine, and our cell lines serve as an essential tool in this pursuit.

At [Your Company Name], we pride ourselves on our commitment to advancing scientific discovery through high-quality, rigorously validated biological products. Our expertise in genetic engineering and cell line development ensures that you receive reliable tools to support your research goals, ultimately contributing to breakthroughs in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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