Gene: MICOS13
Official Full Name: mitochondrial contact site and cristae organizing system subunit 13provided by HGNC
Gene Summary: Involved in cristae formation. Located in mitochondrial crista junction and nucleoplasm. Part of MICOS complex. Implicated in combined oxidative phosphorylation deficiency 37. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27470 | MICOS13 Knockout cell line (HeLa) | Human | MICOS13 | 1:3~1:6 | Negative | Online Inquiry |
KO27471 | MICOS13 Knockout cell line (HCT 116) | Human | MICOS13 | 1:2~1:4 | Negative | Online Inquiry |
KO27472 | MICOS13 Knockout cell line (HEK293) | Human | MICOS13 | 1:3~1:6 | Negative | Online Inquiry |
KO27473 | MICOS13 Knockout cell line (A549) | Human | MICOS13 | 1:3~1:4 | Negative | Online Inquiry |
MICOS13 Gene Knockout Cell Lines are a cutting-edge tool designed to facilitate the study of mitochondrial function and dynamics in mammalian cells. These cell lines have been engineered to selectively disrupt the MICOS13 gene, which plays a crucial role in mitochondrial cristae organization and overall mitochondrial morphology. By knocking out this essential gene, researchers can investigate the downstream effects on mitochondrial biogenesis, bioenergetics, and signaling pathways, thereby enhancing our understanding of metabolic diseases and aging.
The key function of MICOS13 Gene Knockout Cell Lines lies in their ability to model conditions of mitochondrial dysfunction, which is linked to a variety of pathologies, including neurodegenerative diseases, cancer, and metabolic disorders. The knockout mechanism leads to significant changes in mitochondrial architecture, which can be quantitatively assessed using advanced techniques such as electron microscopy and respirometry. This allows for immediate insights into the role of the MICOS13 protein in cellular health and disease.
In research and clinical settings, these cell lines offer immense scientific importance by serving as valuable platforms to screen potential therapeutic compounds and elucidate the molecular mechanisms underlying mitochondrial diseases. They provide a unique environment where gene function can be dissected in a controlled manner, thereby accelerating the discovery of novel interventions and improving our understanding of mitochondrial contributions to cellular pathology.
What sets the MICOS13 Gene Knockout Cell Lines apart from alternative models is their specificity and ease of use. Developed through rigorous genetic engineering techniques, these cell lines exhibit consistent and reproducible knockout efficacy, ensuring reliable results. Additionally, they can be readily integrated into existing workflows, making them an attractive option for both seasoned researchers and newcomers in the field.
The value of MICOS13 Gene Knockout Cell Lines extends beyond laboratory research; they hold the potential for significant clinical implications, particularly in designing targeted therapeutic strategies aimed at restoring mitochondrial function. By enabling clear insights into the molecular intricacies of mitochondrial degeneration, this product is poised to make profound impacts on health sciences.
Our company specializes in providing high-quality biological products developed through innovative research and a commitment to scientific excellence. With extensive expertise in gene editing technology, we strive to equip researchers and clinicians with the tools necessary to advance their studies and improve patient outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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