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MICAL2 Knockout Cell Lines

Gene: MICAL2

Official Full Name: microtubule associated monooxygenase, calponin and LIM domain containing 2provided by HGNC

Gene Summary: The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32961 MICAL2 Knockout cell line (HeLa) Human MICAL2 1:3~1:6 Negative Online Inquiry
KO32962 MICAL2 Knockout cell line (HCT 116) Human MICAL2 1:2~1:4 Negative Online Inquiry
KO32963 MICAL2 Knockout cell line (HEK293) Human MICAL2 1:3~1:6 Negative Online Inquiry
KO32964 MICAL2 Knockout cell line (A549) Human MICAL2 1:3~1:4 Negative Online Inquiry

Background

MICAL2 Gene Knockout Cell Lines are specifically engineered cellular models that have been developed for the targeted disruption of the MICAL2 gene, which encodes for a multifunctional protein involved in various cellular processes including the regulation of actin dynamics, apoptosis, and cell signaling. By employing CRISPR/Cas9 technology, these knockout cell lines provide a powerful tool for researchers aiming to elucidate the biological role of MICAL2 in different physiological and pathological contexts.

The primary function of these knockout cell lines is to facilitate the study of MICAL2's involvement in cellular mechanisms by creating a complete loss-of-function model. Researchers can investigate the effects of MICAL2 deficiency on various cellular functions such as morphology, migration, and pathogenesis of diseases. This has significant implications in cancer research, neurodegeneration studies, and analysis of immune responses, as MICAL2 has been implicated in processes like tumor progression and cellular stress responses.

The scientific importance of MICAL2 Gene Knockout Cell Lines lies in their ability to provide a versatile platform for examination in research and clinical settings. They serve as an invaluable resource for drug discovery efforts targeting the pathways regulated by MICAL2, allowing for screening of therapeutic agents that could potentially modulate its activity. Furthermore, these cell lines are pivotal for genetic manipulation studies and biomarker identification related to various diseases.

One notable advantage of MICAL2 Gene Knockout Cell Lines is their specificity and reproducibility in generating knockout models, which significantly reduce off-target effects compared to traditional gene-editing techniques. This precision allows researchers to obtain clearer insights into gene function and associated biological processes, ultimately paving the way for innovative therapeutic developments.

For researchers and clinicians seeking to deepen understanding of MICAL2's role, these cell lines offer unmatched value through their reliability and unique ability to model specific gene functions. By utilizing these products, scientists can streamline their research efforts and enhance the impact of their findings.

With a strong commitment to advancing biological research, our company ensures the highest quality in providing MICAL2 Gene Knockout Cell Lines and supports the scientific community with cutting-edge tools designed to accelerate discovery and innovation in molecular biology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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