Gene: MGST1
Official Full Name: microsomal glutathione S-transferase 1provided by HGNC
Gene Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36645 | MGST1 Knockout cell line (HeLa) | Human | MGST1 | 1:3~1:6 | Negative | Online Inquiry |
KO36646 | MGST1 Knockout cell line (HCT 116) | Human | MGST1 | 1:2~1:4 | Negative | Online Inquiry |
KO36647 | MGST1 Knockout cell line (HEK293) | Human | MGST1 | 1:3~1:6 | Negative | Online Inquiry |
KO36648 | MGST1 Knockout cell line (A549) | Human | MGST1 | 1:3~1:4 | Negative | Online Inquiry |
MGST1 Gene Knockout Cell Lines represent a crucial advancement in cellular biology, specifically designed to facilitate the study of the multifunctional role of the MGST1 gene in various biological processes. These cell lines are engineered to have the MGST1 gene disrupted, providing researchers an invaluable tool for investigating its functions in cellular detoxification pathways, inflammation, and drug metabolism. By knocking out the MGST1 gene, scientists can elucidate the contributions of this specific gene to oxidative stress responses and assess how its absence might influence cellular phenotypes.
The primary function of MGST1 involves encoding an enzyme that plays a significant role in the conjugation of glutathione to electrophilic compounds, thus aiding in detoxification processes. By utilizing these knockout cell lines, researchers can study the consequent effects of MGST1 deficiency on cellular viability, proliferation, and response to oxidative stress, which are often central themes in cancer research, pharmacology, and toxicology.
This product is not merely an experimental tool but a gateway into understanding the complex biological interactions facilitated by the MGST1 gene. In clinical settings, insights gained from using MGST1 knockout lines can translate into improved therapeutic strategies that target specific metabolic pathways, potentially leading to better patient outcomes in diseases linked with oxidative stress.
One of the key advantages of the MGST1 Gene Knockout Cell Lines compared to alternatives is the precision with which they allow for the study of MGST1’s absence, as opposed to merely observing reduced gene expression or enzyme activity. This knockout approach results in a more definitive determination of the gene’s role in various cellular contexts, thus enhancing the reliability of experimental data.
For researchers and clinicians looking to advance their work in gene function and drug response studies, these cell lines offer a distinct advantage. By leveraging our expertly engineered cell lines, users can expect reproducible results that help drive forward their investigations.
Our company specializes in providing high-quality, genetically modified cell lines tailored to meet the demands of contemporary research. Backed by extensive expertise in molecular biology and cellular engineering, our offerings empower the scientific community to unlock novel discoveries and make impactful advancements in biological research.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.