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MGRN1 Knockout Cell Lines

Gene: MGRN1

Official Full Name: mahogunin ring finger 1provided by HGNC

Gene Summary: Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10029 MGRN1 Knockout cell line (HeLa) Human MGRN1 1:3~1:6 Negative Online Inquiry
KO10030 MGRN1 Knockout cell line (HCT 116) Human MGRN1 1:2~1:4 Negative Online Inquiry
KO10031 MGRN1 Knockout cell line (HEK293) Human MGRN1 1:3~1:6 Negative Online Inquiry
KO10032 MGRN1 Knockout cell line (A549) Human MGRN1 1:3~1:4 Negative Online Inquiry

Background

MGRN1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the MGRN1 gene, which is implicated in various biological processes such as endosomal sorting and protein degradation. These cell lines provide researchers with a powerful tool to investigate the specific roles and regulatory mechanisms of MGRN1, allowing for a deeper understanding of its involvement in disease pathways, particularly in cancer and neurodegenerative disorders.

The key function of MGRN1 involves its role in the ubiquitin-proteasome system, where it assists in tagging proteins for degradation and modulating cellular responses to stress. By leveraging MGRN1 Gene Knockout Cell Lines, scientists can dissect the downstream effects of losing MGRN1 function, facilitating studies on cellular homeostasis, apoptosis, and signal transduction pathways. These insights are critical for developing targeted therapies and understanding pathological mechanisms that arise from MGRN1 dysregulation.

The scientific importance of these cell lines extends to both basic and applied research contexts. In a clinical setting, they can serve as models for therapeutic research, including drug discovery and validation, where understanding the impact of MGRN1 inhibition could lead to novel interventions. Additionally, their utility in functional genomics studies can enhance the identification of biomarkers and therapeutic targets.

What sets MGRN1 Gene Knockout Cell Lines apart from alternative models is their specificity and reliability. Each cell line undergoes rigorous validation to ensure the complete knockout of the MGRN1 gene, providing researchers with consistent and reproducible results. Furthermore, these cell lines are compatible with various assays, including high-throughput screening techniques, making them an attractive choice for time-sensitive research.

For researchers and clinicians seeking to elucidate the complexities of gene function in health and disease, MGRN1 Gene Knockout Cell Lines offer a valuable resource that enhances experimental rigor and provides clarity in functional analyses. Our company is committed to advancing scientific knowledge by providing high-quality, functional cell lines, backed by a team of experts with extensive experience in genetic engineering and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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