Gene: MFGE8
Official Full Name: milk fat globule EGF and factor V/VIII domain containingprovided by HGNC
Gene Summary: This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07393 | MFGE8 Knockout cell line (HeLa) | Human | MFGE8 | 1:3~1:6 | Negative | Online Inquiry |
KO07394 | MFGE8 Knockout cell line (HCT 116) | Human | MFGE8 | 1:2~1:4 | Negative | Online Inquiry |
KO07395 | MFGE8 Knockout cell line (HEK293) | Human | MFGE8 | 1:3~1:6 | Negative | Online Inquiry |
KO07396 | MFGE8 Knockout cell line (A549) | Human | MFGE8 | 1:3~1:4 | Negative | Online Inquiry |
MFGE8 Gene Knockout Cell Lines are specifically engineered cellular models in which the Milk Fat Globule-Epidermal Growth Factor 8 (MFGE8) gene has been systematically inactivated. This product enables researchers to investigate the functional roles of MFGE8 in various biological processes, including cell adhesion, immune response modulation, and tissue homeostasis. By utilizing CRISPR-Cas9 technology or similar gene-editing methodologies, these knockout cell lines provide a precise approach to dissecting MFGE8's contribution in health and disease.
The key function of these knockout cell lines lies in their ability to mimic pathological conditions, facilitating the study of MFGE8's involvement in diverse phenomena such as inflammatory diseases, cancer progression, and metabolic disorders. Due to the absence of MFGE8, researchers can analyze changes in cellular behavior, signaling pathways, and gene expression profiles, providing critical insights into the gene's biological significance.
In the context of scientific research and clinical applications, MFGE8 Gene Knockout Cell Lines serve as invaluable tools for drug discovery and therapeutic development, enabling screening for potential compounds targeting MFGE8-related pathways. Unlike alternative cell lines, where the MFGE8 gene is present, these knockout models eliminate complicating factors, offering clearer data and more definitive conclusions about the gene's functions.
The unique advantage of our MFGE8 Gene Knockout Cell Lines lies in their robust genetic modification and high reproducibility, ensuring consistent performance across experiments. By choosing our product, researchers can accelerate their investigations and yield reliable results that are critical for advancing knowledge in fields ranging from immunology to oncology.
As a leader in biological products, our company is committed to delivering high-quality gene-editing tools backed by extensive scientific expertise. We continually strive to enable groundbreaking discoveries and enhance the research capabilities of scientists and clinicians worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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