Gene: MEST
Official Full Name: mesoderm specific transcriptprovided by HGNC
Gene Summary: This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO36661 | MEST Knockout cell line (HeLa) | Human | MEST | 1:3~1:6 | Negative | Online Inquiry |
KO36662 | MEST Knockout cell line (HCT 116) | Human | MEST | 1:2~1:4 | Negative | Online Inquiry |
KO36663 | MEST Knockout cell line (A549) | Human | MEST | 1:3~1:4 | Negative | Online Inquiry |
MEST Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to provide insights into the functional role of the MEST gene, known for its involvement in growth regulation, metabolism, and epigenetic processes. These cell lines are produced through advanced CRISPR-Cas9 technology, which allows for high precision in knocking out the MEST gene, thereby facilitating the study of its effects on cellular behavior, signaling pathways, and metabolic functions.
The primary function of the MEST Gene Knockout Cell Lines is to act as a reliable tool for researchers investigating the implications of MEST in various biological contexts, including cancer research and metabolic disorders. By examining the phenotypic and molecular changes that arise from the absence of MEST, scientists can uncover its biological pathways and interactions. The precise gene editing methodology employed ensures that these models maintain genomic integrity while effectively eliminating MEST expression, allowing for controlled studies.
The scientific importance of these cell lines extends to both basic research and clinical applications. They serve as critical platforms for drug discovery, providing valuable data on how MEST-related pathways may influence therapeutic responses. Moreover, their application can lead to breakthroughs in understanding how alterations in MEST gene expression contribute to disease pathogenesis and progression.
One significant advantage of MEST Gene Knockout Cell Lines is their ability to offer a more focused analysis of the MEST gene compared to traditional models, such as siRNA knockdown strategies, which may result in partial gene silencing and reversible effects. Additionally, these cell lines can be customized for particular cell types, enhancing their relevance for specific research questions.
For researchers and clinicians, investing in MEST Gene Knockout Cell Lines means gaining access to a powerful tool that can streamline experiments, reduce variability, and improve reproducibility in findings. These enhanced research capabilities can accelerate the translation of basic science to clinical innovations, ultimately contributing to more effective treatment strategies.
Our company specializes in providing high-quality biological products that empower scientific research and innovation. With a focus on cutting-edge technology and comprehensive support, we are committed to enabling our customers to achieve impactful scientific breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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