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MEF2C Knockout Cell Lines

Gene: MEF2C

Official Full Name: myocyte enhancer factor 2Cprovided by HGNC

Gene Summary: This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10611 MEF2C Knockout cell line (HeLa) Human MEF2C 1:3~1:6 Negative Online Inquiry
KO10612 MEF2C Knockout cell line (HCT 116) Human MEF2C 1:2~1:4 Negative Online Inquiry
KO10613 MEF2C Knockout cell line (HEK293) Human MEF2C 1:3~1:6 Negative Online Inquiry

Background

MEF2C Gene Knockout Cell Lines are engineered cellular systems specifically designed to study the function and regulation of the MEF2C (myocyte enhancer factor 2C) gene, a transcription factor crucial in muscle and neuronal differentiation. By employing CRISPR/Cas9 gene-editing technology, these cell lines have been modified to completely disrupt the MEF2C gene, allowing researchers to investigate the downstream effects of its absence on cellular behavior, development, and disease pathways.

The primary function of the MEF2C Gene Knockout Cell Lines is to facilitate insights into gene regulation mechanisms and cellular responses impacted by the loss of MEF2C activity. This disruption leads to altered gene expression profiles, which researchers can analyze to better understand the role of MEF2C in processes such as cell growth, apoptosis, and synaptic plasticity. These cell lines serve as essential tools for elucidating pathways involved in cardiac and skeletal muscle diseases, as well as neurological disorders.

From a scientific perspective, the MEF2C Gene Knockout Cell Lines are invaluable for both fundamental research and potential clinical applications. They enable scientists to model diseases, explore therapeutic targets, and contribute to drug discovery efforts. This is particularly relevant in the context of conditions like congenital heart defects and neurodegenerative diseases, where understanding MEF2C interaction can lead to innovative treatment strategies.

What sets our MEF2C Gene Knockout Cell Lines apart from traditional cell lines is the precision of the gene-editing technique used, ensuring high specificity and reproducibility. Unlike other models, these lines have been rigorously validated for efficiency and off-target effects, providing researchers a reliable solution with enhanced confidence in their experimental outcomes.

The value of these cell lines to researchers and clinicians is substantial, as they provide an effective platform to investigate gene function, validate target engagement in drug discovery, and ultimately pave the way for novel therapeutic interventions. Our company stands at the forefront of genetic engineering, offering a comprehensive portfolio of advanced biological products that empower researchers in their quest for scientific knowledge and clinical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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