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MED23 Knockout Cell Lines

Gene: MED23

Official Full Name: mediator complex subunit 23provided by HGNC

Gene Summary: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00458 MED23 gRNA5-gRNA6 KO plasmid MED23 $850
GP00608 MED23 gRNA1-gRNA2 KO plasmid MED23 $850
GP00611 MED23 gRNA3-gRNA4 KO plasmid MED23 $850
KO00702 MED23 Knockout cell line(HEK293) Human MED23 1:3~1:6 Negative Online Inquiry
KO16259 MED23 Knockout cell line (HeLa) Human MED23 1:3~1:6 Negative Online Inquiry
KO16260 MED23 Knockout cell line (HCT 116) Human MED23 1:2~1:4 Negative Online Inquiry
KO16261 MED23 Knockout cell line (A549) Human MED23 1:3~1:4 Negative Online Inquiry

Background

MED23 Gene Knockout Cell Lines are specialized cellular models that have undergone targeted gene knockout techniques to disable the expression of the MED23 gene, a crucial component of the Mediator complex involved in transcription regulation. These cell lines provide researchers with a unique tool for studying the role of MED23 in cellular processes such as gene expression, cell growth, differentiation, and response to external stimuli. By creating a specific knockout of the MED23 gene, scientists can better understand its function and contribution to various biological pathways.

The primary mechanism of action involves gene editing technologies, such as CRISPR-Cas9, which effectively disrupt the MED23 gene, leading to a loss of function. This loss allows researchers to observe the resultant phenotypic changes, providing insights into the gene's role in regulating transcriptional events and its implications in diseases, including cancer and metabolic disorders. The applications for these knockout cell lines in both fundamental research and therapeutic development are vast, making them invaluable in dissecting the molecular underpinnings of various biological phenomena.

What sets MED23 Gene Knockout Cell Lines apart from alternatives, such as traditional knockdown models, is their ability to provide a complete loss of gene function rather than simply reducing expression levels. This characteristic ensures that any observed effects are directly attributable to the absence of MED23, allowing for more definitive conclusions in experimental outcomes. Moreover, these cell lines can be readily adapted into high-throughput screening formats, facilitating drug discovery and testing.

For researchers and clinicians, these cell lines represent a powerful asset that can accelerate the discovery of novel therapeutic targets and enhance understanding of MED23's role across different biological contexts. The comprehensive and precise capabilities of MED23 Gene Knockout Cell Lines offer significant advantages for advanced biotechnological applications.

Our company, with its dedication to innovation in genetic tools and cellular technologies, stands committed to supporting scientists in their quest to unravel complex biological systems. We provide a comprehensive range of products designed to streamline research and enhance the exploration of gene function, ensuring that our clients are equipped with high-quality, reliable tools for their scientific endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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