Gene: MED13
Official Full Name: mediator complex subunit 13provided by HGNC
Gene Summary: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32438 | MED13 Knockout cell line (HeLa) | Human | MED13 | 1:3~1:6 | Negative | Online Inquiry |
KO32439 | MED13 Knockout cell line (HCT 116) | Human | MED13 | 1:2~1:4 | Negative | Online Inquiry |
KO32440 | MED13 Knockout cell line (HEK293) | Human | MED13 | 1:3~1:6 | Negative | Online Inquiry |
KO32441 | MED13 Knockout cell line (A549) | Human | MED13 | 1:3~1:4 | Negative | Online Inquiry |
MED13 Gene Knockout Cell Lines are innovative biological tools designed to facilitate comprehensive studies of the MED13 gene's role in cellular processes and disease mechanisms. MED13, a pivotal subunit of the Mediator complex, is critically involved in gene transcription regulation and signaling pathways, making its knockout essential for elucidating the gene's biological functions.
These knockout cell lines are engineered to provide a reliable model for investigating the functional consequences of MED13 depletion. The mechanism involves the targeted disruption of the MED13 gene through CRISPR-Cas9 technology, leading to the generation of cell lines that lack functional MED13 protein. This strategic disruption allows researchers to explore alterations in transcriptional regulation, cellular proliferation, differentiation, and response to stimuli in a controlled environment.
The scientific importance of MED13 Gene Knockout Cell Lines cannot be overstated. They serve as vital tools in molecular biology, cancer research, and pharmacology, enabling researchers to dissect the role of MED13 in oncogenesis, metabolic disorders, and hormonal signaling pathways. These models have the potential to accelerate drug discovery and therapeutic development by identifying new targets for intervention.
One of the key advantages of our MED13 knockout cell lines is their high specificity and reproducibility, distinguishing them from conventional transcriptomic studies that rely on RNA interference. Unlike alternative models, these knockout lines ensure a complete loss-of-function scenario, providing clearer insights into MED13's biological roles without residual activity. This precision leads to more accurate data, ultimately enhancing the reliability of research outcomes.
For researchers, clinicians, and biotechnologists, the value of MED13 Gene Knockout Cell Lines lies in their ability to streamline experimental design and improve the understanding of gene function in health and disease. By offering these cell lines, we support the scientific community in driving forward discoveries that could translate into transformative medical advances.
At [Your Company Name], we pride ourselves on our commitment to enhancing research capabilities through cutting-edge products like the MED13 Gene Knockout Cell Lines. With expertise in genetic engineering and a focus on quality, we endeavor to empower scientists in their quest for knowledge and innovation.
Please note that all services are for research use only. Not intended for any clinical use.
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