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ME2 Knockout Cell Lines

Gene: ME2

Official Full Name: malic enzyme 2provided by HGNC

Gene Summary: This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO36679 ME2 Knockout cell line (HeLa) Human ME2 1:3~1:6 Negative Online Inquiry
KO36680 ME2 Knockout cell line (HCT 116) Human ME2 1:2~1:4 Negative Online Inquiry
KO36681 ME2 Knockout cell line (HEK293) Human ME2 1:3~1:6 Negative Online Inquiry
KO36682 ME2 Knockout cell line (A549) Human ME2 1:3~1:4 Negative Online Inquiry

Background

ME2 Gene Knockout Cell Lines are highly specialized cellular models that have undergone precise genetic modification to disable the ME2 gene, an essential component implicated in various metabolic pathways. These knockout cell lines serve as invaluable tools for elucidating the role of ME2 in cellular processes, such as energy metabolism, oxidative stress response, and cellular signaling. By completely removing the expression of the ME2 gene, researchers can investigate the phenotypic consequences and molecular mechanisms that govern metabolic regulation.

The key function of these cell lines lies in their ability to mimic disease states or metabolic disorders by analyzing the absence of ME2. This allows scientists to explore the gene's functions and validate its potential as a therapeutic target. By utilizing engineered ME2 knockout cell lines, researchers can perform a range of assays, such as metabolic profiling, drug sensitivity tests, and pathway analysis, facilitating a deeper understanding of the gene's role in pathophysiological conditions.

The scientific importance of ME2 Gene Knockout Cell Lines cannot be overstated. They offer an innovative platform for basic and applied research in metabolic diseases, cancer, and therapeutic development, which is essential for developing targeted interventions. These models are particularly significant in translational research settings, where understanding gene function directly informs clinical applications.

Compared to conventional cell lines, these knockout models provide a unique selling point through their specificity and ability to produce robust, reproducible data relevant to human physiology. They eliminate the confounding variables associated with endogenous gene expression, thus enhancing the reliability of experimental outcomes.

For researchers and clinicians seeking to advance their understanding of metabolic diseases and discover new therapeutic avenues, ME2 Gene Knockout Cell Lines present an invaluable resource. Their precise genetic editing ensures that studies yield direct insights into gene function and disease mechanisms, streamlining the pathway to innovation.

At the forefront of genetic product development, our company is committed to providing high-quality biological products, including these cutting-edge ME2 Gene Knockout Cell Lines, enriched by our expertise in genetic engineering and continual innovation in biochemical research tools.

Please note that all services are for research use only. Not intended for any clinical use.

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