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MCF2L Knockout Cell Lines

Gene: MCF2L

Official Full Name: MCF.2 cell line derived transforming sequence likeprovided by HGNC

Gene Summary: This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00606 MCF2L Knockout cell line (HeLa) Human MCF2L 1:3~1:6 Negative Online Inquiry
KO06720 MCF2L Knockout cell line (HCT 116) Human MCF2L 1:2~1:4 Negative Online Inquiry
KO06721 MCF2L Knockout cell line (HEK293) Human MCF2L 1:3~1:6 Negative Online Inquiry

Background

MCF2L Gene Knockout Cell Lines are genetically engineered models specifically designed to lack expression of the MCF2L gene, which plays a critical role in various biological processes, including cell proliferation and differentiation. Through precise gene editing techniques, such as CRISPR-Cas9, these cell lines allow researchers to investigate the downstream effects of MCF2L deletion on cellular pathways, signaling mechanisms, and gene expression profiles. By providing a robust platform to study gene function, MCF2L knockout cell lines enable scientists to elucidate the gene's role in health and disease.

The primary function of these cell lines is to serve as a reliable tool for experimental assays aimed at understanding the intricate relationship between MCF2L expression and cellular phenotypes. The knockout of MCF2L has been associated with various physiological and pathological conditions, making these models valuable in investigating cancer biology, neurodevelopmental disorders, and other diseases wherein MCF2L dysregulation may be implicated. The potential applications extend into therapeutic research, where understanding MCF2L pathways can lead to novel interventions in targeted therapies.

One of the unique advantages of MCF2L Gene Knockout Cell Lines is their specificity and reliability. Unlike traditional gene silencing methods, which may lead to off-target effects or incomplete knockdown, these knockout models provide a complete ablation of MCF2L expression, offering clear insights into its biological role. Additionally, they are amenable to high-throughput screening and can be utilized in combination with various assays, including drug response tests, making them a versatile component in experimental design.

The identification and characterization of MCF2L in human health underline the importance of these cell lines to both researchers in academic institutions and clinicians in translational medicine. By integrating these knockout models into research pipelines, users can gain a deeper understanding of gene function, enhancing their ability to develop innovative therapeutic strategies.

Our company prides itself on its extensive experience in genetic engineering and cell line development, ensuring that we provide high-quality, characteristically validated cell lines to advance scientific discovery. The MCF2L Gene Knockout Cell Lines represent a commitment to supporting the scientific community with robust tools for meaningful research outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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