Gene: MAPRE2
Official Full Name: microtubule associated protein RP/EB family member 2provided by HGNC
Gene Summary: The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31349 | MAPRE2 Knockout cell line (HeLa) | Human | MAPRE2 | 1:3~1:6 | Negative | Online Inquiry |
KO31350 | MAPRE2 Knockout cell line (HCT 116) | Human | MAPRE2 | 1:2~1:4 | Negative | Online Inquiry |
KO31351 | MAPRE2 Knockout cell line (HEK293) | Human | MAPRE2 | 1:3~1:6 | Negative | Online Inquiry |
KO31352 | MAPRE2 Knockout cell line (A549) | Human | MAPRE2 | 1:3~1:4 | Negative | Online Inquiry |
MAPRE2 Gene Knockout Cell Lines are expertly engineered cellular models that facilitate the investigation of gene function and the underlying mechanisms of disease. By utilizing targeted CRISPR-Cas9 technology, these cell lines effectively disrupt the MAPRE2 gene, which encodes a microtubule-associated protein pivotal in various cellular processes, including cell division and intracellular transport. This knockout strategy allows researchers to elucidate the role of MAPRE2 in cellular pathways and its implications in conditions such as cancer and neurodegenerative disorders.
The primary function of MAPRE2 Gene Knockout Cell Lines is to enable studies focused on the protein’s contributions to tumorigenesis and cell signaling pathways. These models provide a robust platform for investigating phenotypic changes that arise following the loss of MAPRE2 function, such as alterations in cell proliferation, migration, and response to therapeutic agents. Researchers can leverage these insights to develop new strategies for targeting related pathways in a clinical context, helping to advance the field of personalized medicine.
One of the significant advantages of the MAPRE2 Gene Knockout Cell Lines is their specificity and reproducibility compared to other genetic manipulation methods, such as RNA interference or traditional gene knockdown techniques. The CRISPR-Cas9 system provides a more precise gene knockout, ensuring reliable results that are crucial for robust scientific inquiry. Furthermore, these knockout lines are compatible with an array of assays, including high-throughput screening, making them versatile tools in both basic and translational research.
The value of MAPRE2 Gene Knockout Cell Lines is particularly pronounced for researchers and clinicians aiming to decipher complex biological pathways and develop targeted therapies. By using these cell lines, they can gain a deeper understanding of the MAPRE2 protein’s role in health and disease, ultimately fostering innovations in treatment options.
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