Gene: MAP4K4
Official Full Name: mitogen-activated protein kinase kinase kinase kinase 4provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00612 | MAP4K4 Knockout cell line(HEK293) | Human | MAP4K4 | 1:3~1:6 | Negative | Online Inquiry |
KO10663 | MAP4K4 Knockout cell line (HeLa) | Human | MAP4K4 | 1:3~1:6 | Negative | Online Inquiry |
KO10664 | MAP4K4 Knockout cell line (HCT 116) | Human | MAP4K4 | 1:2~1:4 | Negative | Online Inquiry |
KO10665 | MAP4K4 Knockout cell line (A549) | Human | MAP4K4 | 1:3~1:4 | Negative | Online Inquiry |
MAP4K4 Gene Knockout Cell Lines are innovative biological tools specifically designed to facilitate the study of the MAP4K4 gene, a serine/threonine kinase that plays a pivotal role in various cellular processes, including inflammation, cell proliferation, and apoptosis. These cell lines are engineered to lack functional MAP4K4 gene expression, enabling researchers to dissect the pathways and mechanisms influenced by this gene, ultimately leading to deeper insights into its contribution to disease states, particularly in cancer and metabolic disorders.
The key function of MAP4K4 Gene Knockout Cell Lines lies in their ability to serve as a blank slate for investigating the gene's signaling pathways. By utilizing CRISPR-Cas9 technology for precise gene editing, these cell lines allow for the assessment of the effects of MAP4K4 ablation on cellular behaviors such as growth rates, migration, and response to treatment. Researchers can employ these cell lines to elucidate the downstream effects of MAP4K4 signaling and identify potential therapeutic targets within the MAPK pathways, making them invaluable in understanding disease mechanisms.
Scientifically, the significance of MAP4K4 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, these cell lines can aid in the development of targeted therapies and personalized medicine approaches, particularly for conditions associated with aberrations in MAP4K4 pathways. The ability to mimic disease phenotypes in vitro enhances the translational potential of research findings, leading to more effective treatment strategies.
One of the product's unique selling points is its specificity and reliability compared to other alternatives on the market, such as generalized knockout or wild-type cell lines. Researchers benefit from the assurance that their experiments are directly associated with MAP4K4's absence, thereby providing clearer data and insights. Additionally, these cell lines are produced under stringent quality control measures, ensuring high viability and performance, which are crucial for reproducible scientific results.
For researchers and clinicians invested in understanding the molecular underpinnings of disease or developing groundbreaking treatments, MAP4K4 Gene Knockout Cell Lines represent an essential asset. They empower scientific exploration and innovation at the cutting edge of biomedical research.
Our company, with its extensive expertise in molecular biology and commitment to developing high-quality biological products, is dedicated to supporting the scientific community with robust, reliable tools like the MAP4K4 Gene Knockout Cell Lines, paving the way for future discoveries and therapeutic advancements.
Please note that all services are for research use only. Not intended for any clinical use.
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