Gene: MAP3K8
Official Full Name: mitogen-activated protein kinase kinase kinase 8provided by HGNC
Gene Summary: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10670 | MAP3K8 Knockout cell line (HeLa) | Human | MAP3K8 | 1:3~1:6 | Negative | Online Inquiry |
KO10671 | MAP3K8 Knockout cell line (HCT 116) | Human | MAP3K8 | 1:2~1:4 | Negative | Online Inquiry |
KO10672 | MAP3K8 Knockout cell line (HEK293) | Human | MAP3K8 | 1:3~1:6 | Negative | Online Inquiry |
KO10673 | MAP3K8 Knockout cell line (A549) | Human | MAP3K8 | 1:3~1:4 | Negative | Online Inquiry |
MAP3K8 Gene Knockout Cell Lines are advanced biological tools engineered to facilitate the study of the MAP3K8 gene, also known as Mitogen-Activated Protein Kinase Kinase Kinase 8, which plays a crucial role in cellular signaling pathways involved in inflammation and apoptosis. The knockout mechanism aims to create cellular models devoid of the MAP3K8 protein, enabling researchers to observe the gene's functional impacts on cellular behavior and signaling cascades.
These cell lines are vital for researchers in understanding the specific pathways influenced by MAP3K8, particularly in conditions like cancer, where its expression is often dysregulated. The knockout methodology typically employs CRISPR-Cas9 gene editing to ensure precise deletion of the MAP3K8 gene, which allows for clear demarcation of its function in a controlled environment. By utilizing these cell lines, scientists can conduct in-depth analyses of cellular responses to various stimuli, providing insights that are crucial for developing targeted therapies.
One of the main advantages of MAP3K8 Gene Knockout Cell Lines is their high specificity and reproducibility compared to traditional knockdown methods, such as RNA interference, which may result in incomplete or transient gene silencing. This precision allows for more reliable data and conclusions in experimental settings. These cell lines also serve as a critical platform for drug discovery and development, offering a robust model for validating therapeutic candidates aimed at modulating MAP3K8-related pathways.
For researchers, clinicians, and biotech companies focused on cancer research and treatment, the MAP3K8 Gene Knockout Cell Lines represent an invaluable resource for advancing our understanding of disease mechanisms and therapeutic targets. By employing these expertly crafted cell lines, users can maximize their research efficiency and enhance the likelihood of successful outcomes.
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Please note that all services are for research use only. Not intended for any clinical use.
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