Gene: MAP3K7
Official Full Name: mitogen-activated protein kinase kinase kinase 7provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO11042 | MAP3K7 Knockout cell line (HeLa) | Human | MAP3K7 | 1:3~1:6 | Negative | Online Inquiry |
KO11043 | MAP3K7 Knockout cell line (HCT 116) | Human | MAP3K7 | 1:2~1:4 | Negative | Online Inquiry |
KO11044 | MAP3K7 Knockout cell line (HEK293) | Human | MAP3K7 | 1:3~1:6 | Negative | Online Inquiry |
KO11045 | MAP3K7 Knockout cell line (A549) | Human | MAP3K7 | 1:3~1:4 | Negative | Online Inquiry |
MAP3K7 Gene Knockout Cell Lines are genetically engineered cellular models that lack the expression of the MAP3K7 gene, which encodes the mitogen-activated protein kinase kinase kinase 7, an essential component in various signaling pathways crucial for cell proliferation, differentiation, and stress responses. These knockout cell lines provide a valuable tool for researchers investigating the intricate roles of MAP3K7 in cellular mechanisms, particularly in the context of inflammatory responses and cancer biology.
The primary function of MAP3K7 involves the activation of downstream signaling pathways, notably the NF-κB and JNK pathways, which mediate cellular responses to stress and promote survival in adverse conditions. By utilizing MAP3K7 knockout cell lines, researchers can elucidate the gene's specific contributions to various signaling cascades, assess its involvement in pathological processes, and explore potential therapeutic targets for disease intervention.
The scientific importance of MAP3K7 knockout cell lines extends to their applications in both basic and translational research. They serve as vital models for studying disease mechanisms such as tumor progression and immune responses, leading to better understanding and development of novel therapeutic strategies. In clinical settings, findings derived from these models may inform patient treatment plans and enhance personalized medicine approaches.
One of the key advantages of our MAP3K7 Gene Knockout Cell Lines is their reliability and reproducibility, which are critical for experimental validation. Unlike alternatives that may produce variable results, our cell lines are meticulously validated and characterized to ensure consistent performance in a variety of assays. Additionally, they are compatible with a range of techniques, such as gene editing and high-throughput screening, allowing for flexible experimental designs.
For researchers and clinicians seeking to deepen their understanding of MAP3K7's biological roles and its implications in health and disease, these knockout cell lines represent an indispensable resource. Leveraging our extensive expertise in genetic engineering and cell line development, we provide high-quality products that empower scientific exploration and advance medical innovation. Our commitment to excellence and support ensures that users can achieve their research goals effectively and efficiently.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.