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MAP3K1 Knockout Cell Lines

Gene: MAP3K1

Official Full Name: mitogen-activated protein kinase kinase kinase 1provided by HGNC

Gene Summary: The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00616 MAP3K1 Knockout cell line (HeLa) Human MAP3K1 1:3~1:6 Negative Online Inquiry
KO10710 MAP3K1 Knockout cell line (HCT 116) Human MAP3K1 1:2~1:4 Negative Online Inquiry
KO10711 MAP3K1 Knockout cell line (HEK293) Human MAP3K1 1:3~1:6 Negative Online Inquiry
KO10712 MAP3K1 Knockout cell line (A549) Human MAP3K1 1:3~1:4 Negative Online Inquiry

Background

MAP3K1 Gene Knockout Cell Lines are advanced biological tools developed for the in-depth study of cellular signaling pathways and their role in various disease mechanisms. Specifically, these cell lines contain targeted deletions of the MAP3K1 gene, which encodes for a serine/threonine kinase involved in the mitogen-activated protein kinase (MAPK) signaling cascade. By disrupting this critical upstream signaling component, researchers can analyze the resulting phenotypic changes in cellular behavior, gene expression, and downstream signaling responses.

The core function of MAP3K1 is to phosphorylate and activate MAPK pathways, which are essential for regulating diverse biological processes, including cell proliferation, differentiation, survival, and apoptosis. The MAP3K1 knockout cell lines facilitate elucidation of these signaling mechanisms, allowing scientists to delve into the molecular underpinnings of conditions such as cancer, inflammation, and developmental disorders. These cell lines are invaluable in both research and clinical settings, providing a reliable model for drug testing, gene therapy investigations, and understanding the effects of specific gene disruptions.

The unique selling point of MAP3K1 Gene Knockout Cell Lines lies in their specificity and reliability. They offer a precise model for studying the consequences of MAP3K1 loss, often leading to results that are more reproducible compared to general knockout models. Furthermore, these cell lines can be customized to express fluorescent markers or other reporter genes, enhancing visualization and tracking of cellular processes.

For researchers and clinicians, the ability to pinpoint the role of MAP3K1 in pathophysiology offers potential avenues for innovative therapeutic strategies. By utilizing these knockout models, users can significantly advance their understanding of both fundamental biology and clinical applications, thus enhancing their research outcomes.

Our company is dedicated to providing high-quality biological products and services that empower the scientific community. With extensive expertise in genetic engineering and cellular models, we stand at the forefront of innovation, ensuring our offerings meet the evolving needs of researchers and clinicians alike.

Please note that all services are for research use only. Not intended for any clinical use.

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