Gene: MAP2K6
Official Full Name: mitogen-activated protein kinase kinase 6provided by HGNC
Gene Summary: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08638 | MAP2K6 Knockout cell line (HeLa) | Human | MAP2K6 | 1:3~1:6 | Negative | Online Inquiry |
KO08639 | MAP2K6 Knockout cell line (HEK293) | Human | MAP2K6 | 1:3~1:6 | Negative | Online Inquiry |
KO08640 | MAP2K6 Knockout cell line (A549) | Human | MAP2K6 | 1:3~1:4 | Negative | Online Inquiry |
MAP2K6 Gene Knockout Cell Lines are genetically engineered cellular models designed to specifically disrupt the MAP2K6 gene, which encodes the mitogen-activated protein kinase kinase 6. This gene plays a critical role in various signaling pathways that regulate cellular responses, including proliferation, differentiation, and apoptosis. By providing a knockout model, these cell lines allow researchers to investigate the physiological and pathological roles of MAP2K6, thereby shedding light on its influence in diverse biological processes.
The key functionality of MAP2K6 Gene Knockout Cell Lines revolves around their capacity to omit gene expression entirely. Researchers utilize CRISPR-Cas9 technology to create precise mutations in the MAP2K6 gene, abolishing its function. This approach enables the study of the downstream effects of MAP2K6 deficiency, offering insights into how its absence can influence cellular signaling cascades and contribute to disease states, such as inflammation and cancer.
Scientifically, these knockout cell lines are of paramount importance, serving as essential tools for elucidating the mechanisms of MAP2K6-related pathways in both basic and applied research. In clinical settings, understanding the role of MAP2K6 could provide a foundation for developing targeted therapeutic strategies that manipulate its signaling pathways to treat various diseases.
One of the significant advantages of MAP2K6 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods that may lead to off-target effects or incomplete inhibition. Moreover, their use allows for reproducibility across different experiments, which is critical in validating the role of MAP2K6 in cellular function.
For researchers and clinicians seeking to explore the intricacies of cellular signaling pathways, these knockout cell lines are invaluable. They offer a clear, controlled environment in which to dissect complex biological interactions, ultimately advancing understanding and enabling innovative therapeutic solutions.
At [Company Name], we specialize in providing high-quality genetic engineering solutions, and our MAP2K6 Gene Knockout Cell Lines are just one example of our commitment to advancing research. With a focus on rigorously-tested, reliable products, we empower scientists to achieve their research goals with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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