Gene: MAP2
Official Full Name: microtubule associated protein 2provided by HGNC
Gene Summary: This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03444 | MAP2 Knockout cell line (HeLa) | Human | MAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO03445 | MAP2 Knockout cell line (HCT 116) | Human | MAP2 | 1:2~1:4 | Negative | Online Inquiry |
KO03446 | MAP2 Knockout cell line (HEK293) | Human | MAP2 | 1:3~1:6 | Negative | Online Inquiry |
KO03447 | MAP2 Knockout cell line (A549) | Human | MAP2 | 1:3~1:4 | Negative | Online Inquiry |
MAP2 Gene Knockout Cell Lines are engineered cellular models specifically designed to elucidate the functions of the microtubule-associated protein 2 (MAP2) gene, which plays a crucial role in neuronal development and function. These cell lines are created using advanced CRISPR-Cas9 technology, allowing for precise knockout of the MAP2 gene, which provides researchers with a unique tool for studying its biological impact.
The key mechanism behind the MAP2 Gene Knockout Cell Lines involves the disruption of MAP2 expression, thereby permitting extensive examination of the alterations in cytoskeletal dynamics, synaptic function, and overall cellular morphology. Researchers can utilize these knockout models to investigate the gene's influence on neurogenesis, neuronal differentiation, and neurodegenerative conditions, providing insight into the molecular mechanisms that underpin various neurological disorders.
The scientific importance of these cell lines is significant in both research and clinical settings, as understanding the role of MAP2 can contribute to the development of therapeutic strategies for neurodevelopmental and neurodegenerative diseases, such as Alzheimer's and Huntington's. The ability to observe the phenotypic changes and cellular responses in a controlled environment enhances the reliability of experimental outcomes.
Compared to other models, MAP2 Gene Knockout Cell Lines offer enhanced specificity in studying the MAP2 gene's pathways, which is often obscured in wild-type cell lines. Their precision not only improves the consistency of experimental results but also accelerates the drug discovery process by providing clear targets for modulatory compounds.
For researchers and clinicians focusing on neurological research, the MAP2 Gene Knockout Cell Lines represent a valuable resource, effectively bridging the gap between basic research and clinical applications. By utilizing these models, users can drive advancements in understanding and potentially treating complex neurological conditions.
Our company specializes in producing high-quality biological products backed by rigorous scientific research and innovation. By choosing MAP2 Gene Knockout Cell Lines, you can be confident in employing a product that embodies excellence in cellular research and offers unparalleled support for your scientific pursuits.
Please note that all services are for research use only. Not intended for any clinical use.
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